Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus(Pharmacognosy)

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概要

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• As an attempt to search for bioactive natural constituents exerting antinociceptive and antiinflammatory activities, we examined the potency of the extract of Rubus coreanus fruits by the activity-guided fractionation. The EtOAc- and BuOH fraction and those alkaline hydrolysates showed significant antinociceptive effects as assessed by writhing-, hot plate- and tail flicks tests in mice and rats as well as antiinflammatory effect in rats with car-rageenan-induced edema. BuOH extract was subjected to column chromatography to obtain a large amount of niga-ichigoside F_1, (1,23-hydroxytormentic acid 28-0-glc), which was again hydrolyzed in NaOH solution to yield an aglycone 23-hydroxytormentic acid (1a). The aglycone, 23-hydroxytormentic acid, was much more potent in both antinociceptive and antiinflammatory tests than the glycoside, niga-ichigoside F_1. The antiinflammatory effects of these compounds were further supported by the reduction of carrageenan-induced lipid peroxidation and hydroxyl radical in serum. These results suggested that 23-hydroxytormentic acid might be an active moiety of niga-ichigoside F_1 present in R. coreanus.

• 社団法人日本薬学会の論文
• 2003-10-01

著者

• PARK Hee-Juhn

  Division of Applied Plant Sciences, Sang-Ji University

• LEE Kyung-Tae

  College of Pharmacy, Kyung-Hee University

• Choi Jongwon

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jong-won

  韓国

• Choi Jong-won

  College Of Pharmacy Kyung-sung University

• Lee Kyung-tae

  韓国

• Lee Kyung-tae

  College Of Pharmacy Kyung-hee University

• Lee Kyung-tae

  Coll. Of Pharmacy Kyung-hee Univerisity

• Lee Kyung-tae

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• Lee Kyung-tae

  Coll. Of Medical Sci. Kyung Hee Univ.

• Lee Kyung-tae

  Department Of Biochemistry College Of Pharmacy Kyung Hee University

• Park Hee-juhn

  Department Of Pharmaceutical Engineering Sangji University

• Park Hee-juhn

  韓国

• Park Hee-juhn

  Division Of Applied Plant Sciences Sangji University

• Park Hee-juhn

  Department Of Botanical Resources Sangi University

• Ryu Jong

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• CHOI Jongwon

  College of Pharmacy, Kyungsung University

• JUNG Hyun-Ju

  Division of Applied Plant Sciences, Sangji University

• HA Joohun

  Medicine, Dongdaemun-ku, Hoegi-Dong, Kyung-Hee University

• YUN Sei-Young

  Division of Applied Plant Sciences, Sangji University

• KO Chang-Duk

  Division of Applied Plant Sciences, Sangji University

• Jeong H‐j

  Dep. Of Oriental Pharmacy Wonkwang Univ.

• Lee Kyung

  College Of Pharmacy Kyung Hee University

• Lee Kyung-won

  韓国

• Lee Kyung‐won

  Kyung Hee Univ. Seoul Kor

• Ryu Jong

  Department Of Oriental Pharmaceutical Science Kyunghee University

• Choi Jong-won

  Coll. Of Pharmacy Kyungsung Univ.

• Ko Chang-duk

  Division Of Applied Plant Sciences Sangji University

• Choi Jung-hye

  Department Of Internal Medicine Hanyang University

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Park Hee-joun

  Department Of Botanical Resources Sangji University

• Choi Jongwon

  College Of Pharmacy Daeyeon-dong Kyungsung University

• Jung Hyun-ju

  Coll. Of Pharmacy And Wonkwang-oriental Medicines Res. Inst. Wonkwang Univ.

• Choi Jung-hye

  Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.

• Choi Jeongeun

  College Of Pharmacy Kyungsung University

• Yun Sei-young

  Division Of Applied Plant Sciences Sangji University

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