Inhibition of Methanol Extract from the Fruits of Kochia scoparia on Lipopolysaccharide-Induced Nitric Oxide, Prostagladin E_2, and Tumor Necrosis Factor-α Production from Murine Macrophage RAW 264.7 Cells (Pharmacognosy)
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概要
- 論文の詳細を見る
In an attempt to search for bioactive natural products exerting antiinflammatory activity, we have evaluated the effects of the methanol extract of the fruits of Kochia scoparia (L.) CHARD. (Chenopodiaceae) on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E_2 (PGE_2), and tumor necrosis factor (TNF)-α release by the macrophage cell line RAW 264.7. Our data indicate that this extract is a potent inhibitor of NO production and it also significantly decreased PGE_2 and TNF-α release. Consistent with these observations, the protein and mRNA expression level of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 was inhibited by MeOH extracts of Kochia scoparia (KSM) in a dose-dependent manner. Furthermore, KSM inhibited the LPS-induced DNA binding activity of nuclear factor-кB (NF-кB), which was associated with prevention of the inhibitor кB degradation. These results suggest that the methanol extract of K. scoparia inhibits LPS-induced iNOS and COX-2 expression by blocking NF-кB activation.
- 社団法人日本薬学会の論文
- 2004-04-01
著者
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SHIN Kyung-Min
College of Pharmacy, Kyung-Hee University
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PARK Hee-Juhn
Division of Applied Plant Sciences, Sang-Ji University
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LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
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CHOI Jong-Won
College of Pharmacy, Kyung-Sung University
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Choi Jongwon
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jong-won
韓国
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Choi Jong-won
College Of Pharmacy Kyung-sung University
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Kim You-ah
Div. Of Marine Environment & Bioscience Korea Maritime Univ.
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Lee Kyung-tae
韓国
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Lee Kyung-tae
College Of Pharmacy Kyung-hee University
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Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
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Lee Kyung-tae
Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University
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Lee Kyung-tae
Coll. Of Medical Sci. Kyung Hee Univ.
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Lee Kyung-tae
Department Of Biochemistry College Of Pharmacy Kyung Hee University
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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Ryu Jong
Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University
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Shin Kyung-min
College Of Pharmacy Kyung-hee University
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Shin Kyung-min
韓国
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KIM Yang-Hee
College of Pharmacy, Kyung-Hee University
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PARK Wan-Su
College of Pharmacy, Kyung-Hee University
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KANG Insug
College of Medicine, Kyung-Hee University
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HA Joohun
College of Medicine, Kyung-Hee University
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Lee Kyung
College Of Pharmacy Kyung Hee University
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Lee Kyung-won
韓国
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Lee Kyung‐won
Kyung Hee Univ. Seoul Kor
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Kim Yun-kyung
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Kim You-ah
韓国
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Kim Y‐k
Wonkwang Univ. Jeonbuk Kor
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Shin Kyung-min
Toxicology Department National Institute Of Toxicological Research Korea Food And Drug Administratio
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Ryu Jong
Department Of Oriental Pharmaceutical Science Kyunghee University
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Choi Jong-won
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jung-hye
Department Of Internal Medicine Hanyang University
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Park Wan-su
College Of Oriental Medicine Kyung Hee University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Choi Jung-hye
Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.
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Kang Insug
College Of Medicine Kyung-hee University
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Park Wan-su
College Of Pharmacy Kyung-hee University
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Choi Jeongeun
College Of Pharmacy Kyungsung University
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