Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism(Pharmacognosy)
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概要
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To identify the hepatoprotective component from the leaves of Cirsium setidens (Compositae), the methanolic extract was divided into two fractions, chloroform and butanol fractions, and their hepatoprotective efficacy was evaluated in a rat model of hepatic injury caused by D-galactosamine (GalN). Hepatoprotective activity was measured by the activity of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH). Glutathione metabolism was measured via biochemical parameters such as glutathione (GSH), glutathione reductase (GR), γ-glutamylcysteine synthetase (GCS), glutathione S-transferase (GST), and superoxide dismutase (SOD) levels. We subjected the butanol fraction, which had higher activity, to column chromatography to yield pectolinarin, which was further hydrolyzed to yield pectolinarigenin. Administration (10, 20mg/kg, p.o.) of the main flavonoid glycoside component, pectolinarin, and its aglycone, pectolinarigenin, for 2 weeks significantly decreased the activity levels of AST, ALT, ALP and LDH, indicating that the two compounds have hepatoprotective activity. Pectolinarin and pectolinarigenin also increased activity levels of GSH, GR, GCS, and GST, as well as SOD. The significant effect was only seen in SOD activity. This suggests that the two components exhibit hepatoprotective activity mainly via SOD antioxidant mechanism.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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PARK Hee-Juhn
Department of Botanical Resources, Sangji University
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Choi Jongwon
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jong-won
韓国
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Choi Jong-won
College Of Pharmacy Kyung-sung University
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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CHOI Jongwon
College of Pharmacy, Kyungsung University
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Nam Jung-hwan
韓国
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Nam Jung-hwan
Highland Agriculture Institute Rural Development Administration
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Choi Jong-won
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jung-hye
Department Of Internal Medicine Hanyang University
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Kim Min-young
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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YOO Yeong-Min
Department of Pharmaceutical Engineering, Sangji University
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Kim Min-young
Department Of Materials Science And Engineering Hongik University
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Choi Jongwon
College Of Pharmacy Daeyeon-dong Kyungsung University
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Choi Jung-hye
Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.
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Yoo Yeong-min
Department Of Pharmaceutical Engineering Sangji University
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Choi Jeongeun
College Of Pharmacy Kyungsung University
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Yoo Yeong-min
Department Of Biomedical Engineering College Of Health Science Yonsei University
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