Two New Phenolic Amides from the Seeds of Pharbitis nil
スポンサーリンク
概要
- 論文の詳細を見る
Two new phenolic amides, pharnilatins A (1) and B (2), were isolated from the seeds of Pharbitis nil. These new compounds possess a p-coumaroyl unit with a structurally unique side chain, (2S,3S)-2,3-dihydroxyputrescine. The chemical structures and absolute stereochemistries of the new compounds were determined on the basis of spectroscopic analyses including 1D- and 2D-NMR experiments and chemical reactions. Compounds 1 and 2 exhibited cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cells. However, none of the compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated microglia cells.
- 公益社団法人 日本薬学会の論文
著者
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Choi Sang
Korea Res. Inst. Of Chemical Technol. Daejeon Kor
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Lee Kang
Natural Products Lab. Coll. Of Pharmacy Sungkyunkwan Univ.
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Kim Ki
Natural Products Lab. School Of Pharmacy Sungkyunkwan Univ.
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Son Mi
Dong-A Pharm Institute
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Choi Sang
Korea Food Res. Inst.
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KIM Ki
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University
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