Iodine-Catalyzed Etherification of Morroniside
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概要
- 論文の詳細を見る
In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC_<50> values equal to 20.9μM.
- 公益社団法人日本薬学会の論文
- 2009-01-01
著者
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Saiki Ikuo
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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KOKETSU Mamoru
Division of Instrumental Analysis, Life Science Research Center, Gifu University
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Sakurai Hiroaki
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Sunghwa Fortunatus
Department Of Chemistry Faculty Of Science University Of Dar Es Salaam
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Koketsu Mamoru
Division Of Instrumental Analysis Life Science Research Center Gifu University
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Saiki Ikuo
Division Of Pathogenic Biochemistry Department Of Bioscience Institute Of Natural Medicine Universit
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Sakurai Hiroaki
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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