Social Isolation Stress Impairs the Resistance of Mice to Experimental Liver Metastasis of Murine Colon 26-L5 Carcinoma Cells
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概要
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Our previous study has demonstrated that the exposure of male BALB/c mice to social isolation stress caused a suppressed immune response and enhanced liver metastasis of colon 26-L5 carcinoma cells. To more precisely understand the influence of psychosocial factors on the metastatic process, here we have investigated the effect of social isolation stress on the vulnerability of the host to develop liver metastasis of colon 26-L5 cells, including the time span and incidence of metastatic formation, survival time and chemotherapy response. Isolation stress decreased the time period required for the metastasis formation relative to that in controls. On day 7 after the tumor injection, the 75% incidence of tumor metastasis in the stressed mice was 5 times the 15% incidence in the unstressed mice. When exposed to the challenge of lower cell numbers(0.025, 0.05, 0.1×10^4/mouse)of colon 26-L5 cells, mice subjected to isolation stress developed an elevated incidence of metastasis(33.3, 66.6, and 100%, respectively)as compared with the controls(0, 33.3 and 50%, respectively). The survival time following the tumor inoculation was also shorter in the stressed mice(21.83±1.59d)than in the control mice (24.08±1.68d). Furthermore, the response of liver metastasis to chemotherapy consisting of 2mg/kg cisplatin(CDDP)was worse in the stressed mice than that in unstressed mice. These findings suggested that social isolation stress could significantly impair the resistance of mice to the development of metastasis.
- 社団法人日本薬学会の論文
- 2001-07-01
著者
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Murata J
Department Of Physiology Institute Of Health Sciences Hiroshima University Faculty Of Medicine
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SAIKI Ikuo
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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Saiki Ikuo
富山大学 薬学研究科応用薬理学
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Saiki I
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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WU Wenjuan
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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YAMAURA Takeshi
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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HAYASHI Kazuko
Department of Pathogenic Biochemistry Research Institute for Wakan-Yaku
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Wu Wenjuan
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Yamaura Takeshi
富山医科薬科大学和漢薬研究所
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Yamaura T
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Yamaura Takeshi
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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MURATA Jun
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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MITANI Noriyasu
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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Saiki I
Institute Of Natural Medicine University Of Toyama
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Murata Jun
Department Of Physiology Institute Of Health Sciences Hiroshima University Faculty Of Medicine
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Murata Jun
Department Of Pathogenic Biochemistry
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Saiki Ikuo
Department Of Pathogenic Biochemistry Research Institute For Wakan-yaku (traditional Sino-japanese M
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Saiki Ikuo
Department Of Pathological Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceuti
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Mitani Noriyasu
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Yamaura Takeshi
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Murata Jun
Department Of Applied Physics Faculty Of Engineering University Of Tokyo:presently At Musashi Works
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Hayashi K
Meijo Univ. Nagoya Jpn
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Saiki Ikuo
Department Of Bioscience Institute Of Natural Medicine Toyama University
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Wu Wenjuan
Department of Materials Science, Sichuan University, Chengdu 610064, China
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Wu Wenjuan
Department of Electrical and Computer Engineering, National University of Singapore (NUS), 117576 Singapore
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HAYASHI Kazuko
Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University
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