Expression of the Anti-metastatic Effect Induced by Juzen-taiho-to is Based on the Content of Shimotsu-to Constituents
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概要
- 論文の詳細を見る
We investigated the inhibitory effect of oral administration of Juzen-taiho-to, a Kampo Japanese herbal medicine, and its related formulations on the experimental liver and lung metastasis of tumor cells in vivo. Oral administration of Juzen-taiho-to for 7 d before tumor inoculation significantly reduced the number of liver metastatic colonies of colon 26-L5 carcinoma cells and attenuated the increase of liver weight in a dose-dependent manner ranging from 4 to 40 mg/d. Its oral administration for this same period before tumor inoculation also significantly inhibited lung metastasis of B16-BL6 melanoma cells. Juzen-taiho-to originally consisted of 8 crude drugs derived from Shimotsu-to and Shikunshi-to prescriptions together with two crude drugs (Cinnamomi Cortex and Astragali Radix). Oral administration of Shimotsu-to as well as Juzen-taiho-to for 7 d before tumor inoculation resulted in a significant reduction in the number of metastatic colonies and the liver weight as compared with the control, whereas Shikuhshi-to did not exhibit such an inhibitory effect. Unsei-in containing four Shimotsu-to constituents was also active in inhibiting liver metastasis. Toki-shakuyaku-san and Ninjin-yoei-to, which include all Shimotsu-to constituents except Rehmanniae Radix and Cnidii Rhizoma, respectively, did not show a significant anti-metastatic effect. Rikkunshi-to and Ninjin-yoei-to, which contain Shikunshi-to constituents, did not affect the inhibition of liver metastasis. Hochu-ekki-to treatment before tumor inoculation also led to a significant inhibition of liver metastasis, probably through an inhibitory mechanism different from Juzen-taiho-to. These results suggest that the anti-metastatic effect of Juzen-taiho-to is partly associated with its Shimotsu-to-derived constituents.
- 社団法人日本薬学会の論文
- 1998-07-15
著者
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SAIKI Ikuo
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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Saiki Ikuo
富山大学 薬学研究科応用薬理学
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Saiki I
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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NUNOME Shinyu
Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.
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YAMAURA Takeshi
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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KOMATSU Yasuhiro
Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.,
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Yamaura Takeshi
富山医科薬科大学和漢薬研究所
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Yamaura T
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Yamaura Takeshi
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Komatsu Yasuhiro
北陸大学 薬 薬物治療
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Nunome Shinyu
Kampo And Pharmacognosy Laboratory Tsumura Central Laboratories Tsumura & Co.
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Nunome Shinyu
Kampo And Pharmacognosy Laboratory Tsumura & Co.
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ONISHI Yasuharu
Department of Pathogenic Biochemistry, Research Institute for Wakan-Yaku, Toyama Mecical and Pharmac
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TAUCHI Katsunori
Second Department of Surgery, Faculty of Medicine, Toyama Mecical and Pharmaceutical University
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SAKAMOTO Takashi
Second Department of Surgery, Faculty of Medicine, Toyama Mecical and Pharmaceutical University
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TSUKADA Kazuhiro
Second Department of Surgery, Faculty of Medicine, Toyama Mecical and Pharmaceutical University
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Komatsu Y
Tsumura Central Research Laboratories Tsumura And Co.
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Komatsu Y
Central Research Laboratories Tsumura & Co
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Komatsu Yasuhiro
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Komatsu Yasuhiro
Department Of Serology Kanazawa Medical University
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Ohnishi Yasuharu
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Yamaura Takeshi
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Tsukada Kazuhiro
Second Department Of Surgery Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Tauchi Katsunori
Second Department Of Surgery Faculty Of Medicine Toyama Mecical And Pharmaceutical University
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Komatsu Y
National Institute Of Advanced Industrial Science And Technology
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Komatsu Y
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Tazawa K
Second Department Of Surgery And School Of Nursing Faculty Of Medicine Toyama Medical And Pharmaceut
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Sakamoto T
Second Department Of Surgery Toyama Medical And Pharmaceutical University
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Ohnishi Y
Pharmaceutical Research Lab. Taiho Pharmaceutical Co. Ltd.
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Tsukada K
Second Department Of Surgery Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Komatsu Y
Res. Center Eishogen Co. Ltd. Saitama Jpn
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Sakamoto Takashi
Second Department Of Surgery And School Of Nursing Faculty Of Medicine Toyama Medical And Pharmaceut
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Tazawa Kenji
Second Department Of Surgery And School Of Nursing Faculty Of Medicine Toyama Medical And Pharmaceut
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Saito Tetsuya
Research & Development Center Fuso Pharmaceutical Industries
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Komatsu Yasuhiro
Kampo & Pharmacognosy Laboratory Tsumura & Co.
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Saiki Ikuo
Department Of Bioscience Institute Of Natural Medicine Toyama University
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine
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Sakamoto Takashi
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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