Pharmacoepidemiological study of the clinical efficacy of Sho-saiko-to (Xiao-Chai-Hu-Tang) in chronic liver disease patients
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概要
- 論文の詳細を見る
肝機能に対する小柴胡湯の影響を薬剤疫学の手法を応用して検討した。対象は1995年9月から1996年9月までの間に北里大学病院を継続受診し,小柴胡湯を含む内服薬で薬物療法を受けていた全外来患者609名とした。そのうち,1996年3月の時点で小柴胡湯のみを中止し,他の治療薬を継続服用した315名を小柴胡湯服用中止群とした。また,調査期間中,小柴胡湯による治療を継続していた294名を小柴胡湯服用継続群として肝機能の変動を観察した。その結果,小柴胡湯服用継続群は,AST,ALTなどトランスアミナーゼ値は良好にコントロールされていたが,小柴胡湯服用中止群は中止後から徐々に肝機能が悪化する傾向が観察された。γ-GTP,LDH,ALP,総ビリルビン,コリンエステラーゼの各値も同様の傾向を示した。また,総コレステロール,アルブミン,総蛋白の各値に関しては大きな変動が観察されなかった。肺炎などの重篤な副作用は今回の調査においては両群とも観察されなかった。間質性肺炎は小柴胡湯の有害作用として位置づけ常に注意を払うと同時に,単にノンコンプライアンスを助長するような情報提供は慎むべきであると考えられた。さらに,今後は発症の頻度など,詳細な情報に基づいたフォローアップが必要であると考えられた。特に,肝機能悪化に伴う社会的損失や医療費の増加を抑制する意味でも,薬剤疫学を応用した小柴胡湯に関する医薬品情報は重要であると考えられた。
- 和漢医薬学会の論文
- 2001-06-20
著者
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Tashiro Shin-ichi
Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn
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TASHIRO Shin-ichi
Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University
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Komatsu Yasuhiro
北陸大学 薬 薬物治療
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赤瀬 朋秀
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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KOMATSU Yasuhiro
Department of Serology, Kanazawa Medical University
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AKASE Tomoko
Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University
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AKASE Tomohide
Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University
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Tashiro Shin-ichi
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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Akase Tomoh
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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Akase Tomoko
Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University
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Tashiro Shin-ichi
Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University
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Komatsu Y
Tsumura Central Research Laboratories Tsumura And Co.
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Komatsu Y
Central Research Laboratories Tsumura & Co
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Komatsu Yasuhiro
Department Of Serology Kanazawa Medical University
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Tashiro S
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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ISHIBASHI Akira
Department of Mechanical Engineering, Kumamoto Institute of Technology
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SHIMADA Shigehiko
Department of Pharmacy, Kitasato University Hospital
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Komatsu Y
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Akase Tomohide
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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SAGAWA Ken-ichi
Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University
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KANEKO Masakazu
Medical Support Business Unit, BELLSYSTEM24, Inc.
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Kaneko Masakazu
Medical Support Business Unit Bellsystem24 Inc.
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Komatsu Y
Res. Center Eishogen Co. Ltd. Saitama Jpn
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Shimada Shigehiko
Department Of Hospital Pharmacy Kitasato University Hospital
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Ishibashi Akira
Department Of Mechanical Engineering Saga University
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Ishibashi Akira
Department Of Urology Kitasato University School Of Medicine
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Komatsu Yasuhiro
Department Of Electrical Engineering Tokai University
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Sagawa Kenichi
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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Ishibashi Akira
Department Of Dermatology National Defense Medical College
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ISHIBASHI Akira
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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