単離灌流腎を用いたラット腎に対する五苓散の薬理効果に関する実験的検討

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Pharmacological actions of "Gorei-san" extract granule on rat's isolated kidney were studied. "Gorei-san" extract granule was administered in advance at oral dose of 40 mg/kg to rats and their kidney was isolated and preserved only in EC solution. Such isolated kidney was designated as a control, which was then compared with a sample of rat's kidney preserved with EC solution to which water-soluble component of "Gorei-san" extract granule was added and kept for 24 hours. The comparison resulted in to histological change or significant difference in urinary potassium value. Further, since there was found no variation or difference in sodium elimination between the control and the sample, it was thought that no cell-protecting action was expected in "Gorei-san". Although "Gorei-san" treated rats showed slightly dscreased urinary output when compared with that observed at perfusion, their urination was stable and creatinine clearance was also more stable than control rats. In rats used in the experiment to which "Gorei-san" was orally administered at a dose of 40 mg/ kg, no potassium loss was prevented. But those orally administered at a dose of 100 mg/kg showed a tendency to prevent potassium loss and to increase urinary output. From the above findings, it was likely that water-soluble component of "Gorei-san" extract granule failed to protect organs but kept creatinine clearance stable, and rats administered in advance at an oral dose of 100 mg/kg showed urinary output and urinary potassium value capable of retaining renal function to some extent.
和漢医薬学会の論文
2000-10-20

単離灌流腎を用いたラット腎に対する五苓散の薬理効果に関する実験的検討

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