Effects of Saiko-ka-ryukotsu-borei-to, a Japanese Kampo Medicine, on Tachycardia and Central Nervous System StimulationInduced by Theophylline in Rats and Mice
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概要
- 論文の詳細を見る
Effects of Saiko-ka-ryukotsu-borei-to (SRBT) on theophylline-induced tachycardia in anesthetized rats and theophylline-induced locomotion and convulsions in mice were examined. An intraduodenal administration of SRBT (1 g/kg) prevented theophylline (5 mg/kg, i.v.)-induced tachycardia in rats. SRBT also attenuated an increase in arterial blood pressure with a slow reduction in heart rate of rats treated with theophylline, with no influence on the plasma level of theophylline. However, SRBT did not change the beating rate of right atrium isolated from rats in the absence or presence of theophylline or isoproterenol. The locomotor activity of theophylline in mice was reduced by the treatment with SRBT. Furthermore, the latency of convulsions in mice induced by administration of theophylline at a higher dose (240 mg/kg, i.p.) was prolonged by treatment with SRBT (1 g/kg, p.o.) and seven out of fifteen mice were saved from death due to convulsions. These results suggest that theophylline-induced tachycardia and central nervous stimulation are suppressed by SRBT and that SRBT may reduce the undesirable actions of theophylline on the cardiovascular and central nervous systems.
- 社団法人 日本薬理学会の論文
- 1999-03-01
著者
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Komatsu Yasuhiro
北陸大学 薬 薬物治療
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HAYASHI HISAO
Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University
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SANAE Fujiko
Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University
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KOMATSU Yasuhiro
Department of Serology, Kanazawa Medical University
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Sanae F
Hokuriku Univ. Kanazawa Jpn
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Sanae Fujiko
Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar
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Sanae Fujiko
Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku University
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Sanae Fujiko
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Chisaki Keigo
Central Research Laboratories Tsumura & Co.
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Chisaki Keigo
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
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Komatsu Y
Tsumura Central Research Laboratories Tsumura And Co.
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Komatsu Y
Central Research Laboratories Tsumura & Co
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Komatsu Yasuhiro
Department Of Serology Kanazawa Medical University
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Hayashi Hisao
Sony Corp. Research And Development Dept. Semiconductor Group
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Hayashi Hisao
Department Of Medicine Faculty Or Pharmaceutical Sciences Hokuriku University
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Hayashi Hisao
Department Of Medicine Faculty Of Pharmaceutical Sciences Hokuriku University
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Komatsu Y
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Komatsu Y
Res. Center Eishogen Co. Ltd. Saitama Jpn
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Komatsu Yasuhiro
Department Of Electrical Engineering Tokai University
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Hayashi Hisao
Department Of Medicine Aichi Gakuin University School Of Pharmacy
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Chisaki Keigo
Department of Cardiovascular Medicine, School of Medicine, University of Tokyo
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