EFFECT OF β-ADRENERGIC STIMULANTS ON CYTOTOXICITY OF MITOMYCIN C IN HeLa CELLS
スポンサーリンク
概要
- 論文の詳細を見る
Effects of several autonomic agents on the cytotoxicity of mitomycin C in HeLa cells were studied. When β-adrenergic stimulants such as isoproterenol, epinephrine, terbutaline and turobuterol were added at concentrations over 10<SUP>14</SUP> M 15 to 60 min before mitomycin C, the colony-forming ability of HeLa cells was significantly inhibited more than by mitomycin C alone. The action of isoproterenol and epinephrine on the colony-forming ability of the cells was abolished by propranolol. The intracellular cyclic AMP level of HeLa cells reached the peak of about twofold the basal level at 30 min after the addition of 10<SUP>-8</SUP> M isoproterenol. In combination with mitomycin C, the high level of intracellular cyclic AMP induced by isoproterenol was maintained for a significantly longer period in comparison with that by isoproterenol alone, while mitomycin C alone caused essentially no change in the cyclic AMP level. The pretreatment with dibutyryl cyclic AMP also enhanced the effect of mitomycin C. From these findings, it is strongly suggested that the synergistic effect of β-adrenergic stimulants on the cytotoxicity of mitomycin C is mediated via stimulation of the β-adrenoceptors of HeLa cells which elevates the intracellular cyclic AMP for a long time in combination with mitomycin C.
- 社団法人 日本薬理学会の論文
著者
-
Sanae Fujiko
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
-
Iwasaki Masashi
Department of Applied Mathematics and Physics, Graduate School of Informatics, Kyoto University
-
Miyamoto Kenichi
Department Of Hospital Pharmacy And Department Of Medicinal Informatics Graduate School Of Medical S
-
KOSHIURA RYOZO
Department of Pharmacology, Hokuriku University School of Pharmacy
-
Miyamoto K
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
-
Miyamoto K
Department Of Engineering Physics And Mechanics Kyoto University
-
Miyamoto Kenichi
Department Of Chemistry For Materials Faculty Of Engineering And Graduate School Of Engineering Mie
-
IWASAKI Masashi
Department of Pharmacology, Hokuriku University, School of Pharmacy
関連論文
- Methyl-CpG binding protein 2 gene (MECP2) variations in Japanese patients with Rett syndrome : pathological mutations and polymorphisms
- Genetic Background of Primary Iron Overload Syndromes in Japan
- Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2
- Effects of San'o-shashin-to and the Constituent Herbal Medicines on Theophylline-Induced Increase in Arterial Blood Pressure of Rats
- Convenient synthetic method for 3-(3-substituted indol-2-yl)quinoxalin-2- ones as VEGF inhibitor
- Synthesis of a Capillarisin Sulfur-Analogue Possessing Aldose Reductase Inhibitory Activity by Selective Isopropylation
- Enhancement of Endothelial Nitric Oxide Production by Chenodeoxycholic Acids in Patients with Hepatobiliary Diseases
- Preliminary Result of Parallel double Divide and Conquer
- Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, L-Asp-hexapeptide-conjugated estradiol
- Association of serum NO_x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan
- Influence of Iproniazid on the Combination Effect of Reserpine with Antitumor Agents on L1210
- Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan
- AVAQ 594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis
- C282Y and H63D Mutations in the HFE Gene Have No Effect on Iron Overload Disorders in Japan
- Body iron stores and Iron restoration rate in Japanese patients with chronic Hepatitis C as measured during therapeutic Iron removal revealed neither Increased body iron stores nor effects of C282y and H63d mutations on iron indices
- Studies on Responsiveness of Hepatoma Cells to Catecholamines. VI. Characteristics of Adrenoceptors and Adenylate Cyclase Response in Rat Ascites Hepatoma Cells and Human Hepatoma Cells
- Changes in α_2- and β-Adrenoceptors in Hepatocytes from Rats during Treatment with 3'-Methyl-4-dimethylaminoazobenzene
- Selective drug delivery to bone using acidic oligopeptides
- Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure
- Insulin Signaling in Adipocytes Differentiated from Mouse Stromal MC3T3-G2/PA6 Cells(Biochemistry)
- Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity
- Reversal of P-Glycoprotein-Dependent Resistance to Vinblastine by Newly Synthesized Bisbenzylisoquinoline Alkaloids in Mouse Leukemia P388 Cells(Pharmacology)
- Stimulatory and Inhibitory Effects of Forskolin on Adenylate Cyclase in Rat Normal Hepatocytes and Hepatoma Cells
- COMPARATIVE STUDIES ON THE COMBINED CYTOTOXIC EFFECT OF FORSKOLIN WITH MITOMYCIN C AND RESPONSIVENESS TO FORSKOLIN IN RAT ASCITES HEPATOMA AH66 CELLS AND AH66F CELLS
- HISTOLOGICAL STUDIES ON DEVELOPING CHICK EMBRYOS TREATED WITH AMINOGUANIDINE SULFATE
- Effects of Adrenergic and Nitrergic Blockade on Theophylline : Induced Increase in Peripheral Blood Flow in Rat Ear
- Effects of 9 Kampo Medicines Clinically Used in Hypertension on Hemodynamic Changes Induced by Theophylline in Rats
- Effects of Saiko-ka-ryukotsu-borei-to, a Japanese Kampo Medicine, on Tachycardia and Central Nervous System StimulationInduced by Theophylline in Rats and Mice
- A Xanthine Derivative Denbufylline Inhibits Negative Inotropic Response to Verapamil in Guinea Pig Ventricular Papillary Muscles, Independent of Its Phosphodiesterase Inhibitory Activity
- Structure - Activity Relationhips of Alkylxanthines: Alkyl Chain Elongation at the N1 - or N7 - Position Decreases Cardiotonic Activity in the Isolated Guinea Pig Heart
- CHARACTERISTICS OF ADRENERGIC RECEPTORS OF RAT HEPATOMA CELLS
- EFFECT OF MITOMYCIN C ON THE ACTIVATION OF ADENYLATE CYCLASE IN RAT ASCITES HEPATOMA AH130 CELLS
- EFFECTS OF LOCAL ANESTHETICS, TETRODOTOXIN, ACONITINE AND VERAPAMIL ON THE MECHANORECEPTORS OF ISOLATED FROG HEART
- RECORDING OF PULMONARY AFFERENT ACTIVITIES FROM RECEPTORS IN THE PERFUSED LUNG PREPARATION OF BULLFROG AND EFFECTS OF DRUGS ON THE AFFERENT ACTIVITIES
- EFFECTS OF LOCAL ANESTHETICS ON THE PULMONARY MECHANORECEPTORS OF THE PERFUSED FROG LUNG
- Molecular Dynamics Simulation of a Collapsing Bubble
- ENHANCEMENT OF MITOMYCIN C UPTAKE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA
- Clustering analysis of Keishibukuryogan formulas by use of self-organizing maps
- Self Assembled Growth of Nano Particulate Porous ZnO Thin Film Modified by 2,9,16,23-Tetrasulfophthalocyanatozinc(II) by One-Step Electrodeposition
- THE ACTION OF MITOMYCIN C ON THE INDUCTION OF CYCLIC AMP PHOSPHODIESTERASE AND THE DEVELOPMENT OF DESENSITIZATION OF ADENYLATE CYCLASE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA AH130 CELLS
- RELATIONSHIP BETWEEN ENHANCEMENT OF CYTOTOXIC EFFECT OF MITOMYCIN C AND INCREASE OF INTRACELLULAR CYCLIC ADENOSINE 3' : 5'-MONOphoSPHATE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA CELLS
- EFFECT OF β-ADRENERGIC STIMULANTS ON CYTOTOXICITY OF MITOMYCIN C IN HeLa CELLS
- Initial Characterization of a Fibroblast-loaded Porous Elastin Film Reconstituted by a Novel Crosslinker, Dode-DSP
- Multiform Combination Effects of Smooth Muscle Relaxants with Antitumor Agents in Rat Ascites Hepatoma AH66 Cells
- Comparative Studies on Antitumor Activity of Klebsiella 03 Lipopolysaccharide and Its Polysaccharide Fraction in Mice
- Insulin signaling in adipocytes differentiated from mouse stromal MC3T3-G2/PA6 cells
- Increase of sensitivity and uptake of vinblastine by reserpine in rat ascites hepatoma.
- Structure-activity relationship in N3-alkyl-xanthine derivatives.
- Studies on responsiveness of hepatoma cells to catecholamines. III Difference between the receptor-adenylate cyclase regulating systems in AH130 cells and cultured normal rat liver cells.
- Antitumor activity of methanol extract from roots of Agrimonia pilosa Ledeb.
- Enhancement of the cytotoxic effect of mitomycin C by .BETA.-adrenergic stimulants in rat ascites hepatoma AH130 cells.
- Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa ledeb., on transplantable rodent tumors.
- Studies on responsiveness of hepatoma cells to catecholamines. I. Lack of .BETA.-adrenergic responsiveness in rat ascites hepatoma AH13 cells.
- Studies on responsiveness of hepatoma cells to catecholamines. IV Lack of adrenergic activation of phosphorylase in rat ascites hepatoma cells.
- Studies on responsiveness of hepatoma cells to catecholamines. II. Comparison of .BETA.-adrenergic responsiveness of rat ascites hepatoma cells with cultured normal rat liver cells.
- In vivo effects of drugs that act on the autonomic nervous system on the rat urinary bladder contraction accompanying micturition.
- The effects of tetrodotoxin, papaverine and verapamil on the increase in the rate of spontaneous afferent discharges induced by local anesthetics from the pulmonary mechanoreceptors of the bullfrog.
- Antitumor activity of Klebsiella 03 lipopolysaccharide in mice.
- The effect of baclofen on the urinary bladder contraction accompanying micturition in anesthetized rats.
- Mixed double-multiple precision version of hyperplane constrained method for singular value decomposition
- Combined cytotoxic effect of isoproterenol with alkylating agents in HeLa cells.
- The effects of morphine and morphine-related compounds on the rate of afferent discharges from the pulmonary receptors in bullfrog.
- On the convergence of the V-type hyperplane constrained method for singular value decomposition