EFFECT OF MITOMYCIN C ON THE ACTIVATION OF ADENYLATE CYCLASE IN RAT ASCITES HEPATOMA AH130 CELLS

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概要

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• Isoproterenol (IPN)-stimulated activity of adenylate cyclase was enhanced in a dose-dependent manner by exposure of AH130 cells to mitomycin C (MMC). The enhancement was also observed in prostaglandin E_1-, guanine nucleotide analog-, NaF-, cholera toxin- and forskolin-stimulated activities of the enzyme but not in manganese-stimulated activity. In addition, even when the cells pretreated with islet-activating protein were exposed to MMC, IPN-stimulated activity of adenylate cyclase was enhanced. Anaerobic exposure of AH130 cells to MMC somewhat inhibited IPN-stimulated activity of adenylate cyclase in contrast with aerobic exposure. Exposure of cells to adriamycin also caused enhancement of IPN-stimulated activity of adenylate cyclase but exposure to nitrogen mustard inhibited the enzyme stimulation by IPN. The enhancing effect of MMC was lost by the combined treatment with α-tocopherol. From these results, it was shown that MMC modulated the activity of adenylate cyclase, probably through alterations in membrane structure.

• 公益社団法人日本薬学会の論文

著者

• MIYAMOTO Kenichi

  Department of Medical Genetics, Ehime University School of Medicine

• SANAE Fujiko

  Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University

• Sanae F

  Hokuriku Univ. Kanazawa Jpn

• Sanae Fujiko

  Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar

• Sanae Fujiko

  Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku University

• Sanae Fujiko

  Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• MIYAMOTO Kenichi

  Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University

• Miyamoto Kenichi

  Department Of Hospital Pharmacy And Department Of Medicinal Informatics Graduate School Of Medical S

• Matsunaga Takayuki

  Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un

• Koshiura Ryozo

  Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar

• MATSUNAGA TAKAYUKI

  Department of Pharmacology, Hokuriku University School of Pharmacy

• KOSHIURA RYOZO

  Department of Pharmacology, Hokuriku University School of Pharmacy

• Miyamoto K

  Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University

• Koshiura R

  Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar

• Miyamoto K

  Department Of Engineering Physics And Mechanics Kyoto University

• Miyamoto Kenichi

  Department Of Chemistry For Materials Faculty Of Engineering And Graduate School Of Engineering Mie

• MIYAMOTO Kenichi

  Department of Engineering Physics and Mechanics, Kyoto University

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