RELATIONSHIP BETWEEN ENHANCEMENT OF CYTOTOXIC EFFECT OF MITOMYCIN C AND INCREASE OF INTRACELLULAR CYCLIC ADENOSINE 3' : 5'-MONOphoSPHATE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA CELLS
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概要
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Cyclic adenosine 3' : 5'-monophosphate (cyclic AMP) levels in six lines of rat ascites hepatoma cells were determined after the treatment with isoproterenol. The maximum increase of cyclic AMP levels was induced by the treatment with 10^<-7> M of isoproterenol in each cell line, though the difference was observed at the time to reach the maximum levels. Following the treatment with 10^<-7> M of isoproterenol, cyclic AMP levels increased by 55 to 80% of control in AH-44,AH-130 and AH-7974 cells, by 25 to 45% in AH-41C and AH-109A cells, and slightly in AH-13 cells. The combined cytotoxic effect of isoproterenol and mitromycin C was studied using AH-13,AG-44 and AH-130 cells. The cytotoxicity of mitomycin C on AH-44 and AH-130 cells was potentiated by the pretreatment with 10^<-7> M of isoproterenol that was not cytotoxic by itself, but such a potentiation was not observed in AH-13 cells. The cyclic AMP levels were examined in the cells after the combined treatment. Mitomycin C by itself hardly affected the levels in three cell lines. In AH-44 and AH-130 cells, however, the period of the high levels of cyclic AMP was longer in the combined treatment than in the treatment with isoproterenol alone. On the other hand, the cyclic AMP level in AH-13 cells was hardly affected by each agent or the combined treatment. These results suggest that the combination effect of isoproterenol and mitomycin C is closely related to the increase of cyclic AMP in the cells treated with isoproterenol.
- 公益社団法人日本薬学会の論文
著者
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Iwasaki Masashi
Department of Applied Mathematics and Physics, Graduate School of Informatics, Kyoto University
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MIYAMOTO Kenichi
Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University
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Miyamoto Kenichi
Department Of Hospital Pharmacy And Department Of Medicinal Informatics Graduate School Of Medical S
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Matsunaga Takayuki
Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un
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Koshiura Ryozo
Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar
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Iwasaki Masashi
Department Of Pharmacology Hokuriku University School Of Pharmacy
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MATSUNAGA TAKAYUKI
Department of Pharmacology, Hokuriku University School of Pharmacy
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KOSHIURA RYOZO
Department of Pharmacology, Hokuriku University School of Pharmacy
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Miyamoto K
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Koshiura R
Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar
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Miyamoto K
Department Of Engineering Physics And Mechanics Kyoto University
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Miyamoto Kenichi
Department Of Chemistry For Materials Faculty Of Engineering And Graduate School Of Engineering Mie
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MIYAMOTO Kenichi
Department of Engineering Physics and Mechanics, Kyoto University
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