Enhancement of the cytotoxic effect of mitomycin C by .BETA.-adrenergic stimulants in rat ascites hepatoma AH130 cells.
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概要
- 論文の詳細を見る
Among several sympathomimetic drugs, isoproterenol, epinephrine and norepinephrine significantly potentiated the cytotoxic effect and the uptake of MMC into rat ascites hepatoma AH1 30 cells in in vitro experiments, but salbutamol, tulobuterol and phenylephrine did not. The enhancement of MMC uptake into AH130 cells by isoproterenol and norepinephrine was diminished by propranolol but not by phentolamine. These results indicate that the cytotoxic effect and the uptake of MMC is potentiated by the stimulation of β-adrenoceptors, but not by stimulation Of β<SUB>2</SUB>- and α-receptors.
- 公益社団法人 日本薬理学会の論文
著者
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Waki Yoshihiro
Department Of Pharmacology And Pharmaceutics Graduate School Of Natural Science And Technology Kanaz
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MATSUNAGA TAKAYUKI
Department of Pharmacology, Hokuriku University School of Pharmacy
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KOSHIURA RYOZO
Department of Pharmacology, Hokuriku University School of Pharmacy
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Miyamoto Kenichi
Department Of Chemistry For Materials Faculty Of Engineering And Graduate School Of Engineering Mie
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