Effects of 9 Kampo Medicines Clinically Used in Hypertension on Hemodynamic Changes Induced by Theophylline in Rats

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概要

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• We examined the effects of 9 kinds of Kampo medicines, which are clinically used for the treatment of hypertension, on anesthetized rats with increases in arterial blood pressure, heart rate and peripheral blood flow induced by theophylline (5 mg/kg, i.v.) that were partially or completely mediated by endogenous catecholamines. Each Kampo medicine (1 g/kg) was intraduodenaly administered. Shinbu-to caused a severe disturbance of the arterial blood pressure. Saiko-ka-ryukotsu-borei-to, Oren-gedoku-to, San'o-shanshin-to and Dai-jyoki-to had hypotensive effects, while Hachimi-jio-gan, Gosha-jinki-gan, Dai-saiko-to and Choto-san did not have such an effect. Moreover, Saiko-ka-ryukotsu-borei-to attenuated the heart rate. In Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to, a reduction in peripheral blood flow was observed. These results suggest that Saiko-ka-ryukotsu-borei-to, Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to are ameliorative to the hypertension in sympathetic system dominance and Shinbu-to is occasionally dangerous to it.

• 公益社団法人日本薬学会の論文
• 2000-06-01

著者

• Komatsu Yasuhiro

  北陸大学 薬 薬物治療

• HAYASHI HISAO

  Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University

• SANAE Fujiko

  Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University

• KOMATSU Yasuhiro

  Department of Serology, Kanazawa Medical University

• CHISAKI Keigo

  Central Research Laboratories, Tsumura & Co.

• Sanae F

  Hokuriku Univ. Kanazawa Jpn

• Sanae Fujiko

  Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar

• Sanae Fujiko

  Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku University

• Sanae Fujiko

  Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Chisaki Keigo

  Central Research Laboratories Tsumura & Co.

• Komatsu Y

  Tsumura Central Research Laboratories Tsumura And Co.

• Komatsu Y

  Central Research Laboratories Tsumura & Co

• Komatsu Yasuhiro

  Department Of Serology Kanazawa Medical University

• Hayashi Hisao

  Sony Corp. Research And Development Dept. Semiconductor Group

• Hayashi Hisao

  Department Of Medicine Faculty Or Pharmaceutical Sciences Hokuriku University

• AMAGAYA Sakae

  Central Research Laboratories, Tsumura & Co.

• Hayashi Hisao

  Department Of Medicine Faculty Of Pharmaceutical Sciences Hokuriku University

• Komatsu Y

  Kampo And Pharmacognosy Laboratories Tsumura & Co.

• Amagaya Sakae

  Central Research Laboratories Tsumura & Co.

• Komatsu Y

  Res. Center Eishogen Co. Ltd. Saitama Jpn

• Komatsu Yasuhiro

  Department Of Electrical Engineering Tokai University

• Hayashi Hisao

  Department Of Medicine Aichi Gakuin University School Of Pharmacy

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