The Pharmacological Effects of Daikenchuto, a Traditional Herbal Medicine, on Delayed Gastrointestinal Transit in Rat Postoperative Ileus

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概要

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• The effect of Daikenchuto, a traditional herbal medicine, on gastrointestinal hypoperistalsis in postoperative ileus (POI) was investigated. POI was induced by laparotomy with manipulation of the gastrointestine under anesthesia, and gastrointestinal transit was calculated by migration of Evans blue. Daikenchuto (270 – 2700 mg/kg, p.o.) dose-dependently improved the delayed gastrointestinal transit in POI. This effect of Daikenchuto was partially inhibited by SB204070 (1 mg/kg, s.c.), a 5-hydroxytriptamine4 (5-HT4)-receptor antagonist and completely abolished by atropine (1 mg/kg, s.c.), a muscarine-receptor antagonist. Among the constituents of Daikenchuto, the medical herb zanthoxylum fruit (60 mg/kg, p.o.) and maltose syrup (2400 mg/kg, p.o.) significantly ameliorated the delayed gastrointestinal transit, but ginseng and processed ginger did not affect the gastrointestinal transit in the rat POI. The improvement induced by zanthoxylum fruit was also inhibited by atropine or SB204070. In addition, the high osmotic pressure of the maltose syrup (2400 mg/10 mL/kg) was related to the improvement of delayed gastrointestinal transit. These results demonstrated that Daikenchuto ameliorates postoperative hypoperistalsis via cholinergic nerves and 5-HT4 receptors and that osmotic pressure also may be involved in this action. Moreover, zanthoxylum fruit and maltose syrup were crucial medical herbs contributing to the ability of Daikenchuto.

• 社団法人 日本薬理学会の論文
• 2007-08-20

著者

• Kase Y

  Tsumura Research Laboratories Tsumura & Co.

• Kase Yoshio

  ツムラ漢方生薬研究所

• Kase Yoshio

  国立長寿医療センター研究所 老年病研究部

• Kase Yoshio

  Central Research Laboratories Tsumura & Co.

• Kase Yoshio

  Central Research Laboratory Tsumura & Co.

• 加瀬 義夫

  津村薬理研究所

• YUZURIHARA Mitsutoshi

  Central Research Laboratories, Tsumura & Co.

• Sakaguchi Masaru

  Central Research Laboratory Tsumura & Co.

• Sakaguchi Masaru

  College Of Industrial Technology

• Yuzurihara Mitsutoshi

  Tsumura Research Laboratories Tsumura & Co.

• Yuzurihara M

  Tsumura Res. Inst. Medical Evaluation Lab. Ibaraki Jpn

• Yuzurihara Mitsutoshi

  Central Research Laboratory Tsumura & Co.

• Yuzurihara Mitsutoshi

  Kampo & Parmacognosy Laboratory Tsumura & Co.

• Satoh Kazuko

  Central Research Laboratory Tsumura & Co.

• Tokita Yohei

  Central Research Laboratory Tsumura & Co.

• Komatsu Y

  Central Research Laboratories Tsumura & Co

• Mizuhara Yasuharu

  Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo

• Kase Yoshio

  ツムラツムラ研究所

• Komatsu Y

  Res. Center Eishogen Co. Ltd. Saitama Jpn

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