The Effects of Hange-shashin-to on the Content of Prostaglandin E_2 and Water Absorption in the Large Intestine of Rats
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概要
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The effects of Hange-shashin-to (TJ-14) were examined regarding the amount of prostaglandin E_2 (PGE_2) and the water absorbind capacity in the large intestine of rats. Repeated oral administration of TJ-14 at doses of 125 to 1000 mg/kg revealed a significant decrease in PGE_2 content in the colonic mucosa and also the promotion of colonic water absorption in a dose dependent manner. However, there was no remarkable influence on the concentrations of aldosterone and electrolytes in the serum, even at 1000 mg/kg. From these results, it was considered that some of the anti-diarrheal effects of TJ-14 might be based on a repression of the increase in the amount of PGE_2 as well as promotion of the water absorbing capacity of the large intestine. Moreover, it was also suggested that it is possible, by the application of TJ-14,to prevent the loss of water content caused by diarrhea.
- 社団法人日本薬学会の論文
- 1997-09-15
著者
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石毛 敦
(株)ツムラ中央研究所
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石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
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石毛 敦
ツムラ研究本部 医薬評価研究所
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油田 正樹
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
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油田 正樹
Medicinal Evaluation Laboratory Tsumura Research Institute
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ISHIGE Atsushi
株式会社ツムラ 研究本部 医薬評価研究所
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Aburada M
Fac. Of Pharmacy Musashino Univ.
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Aburada M
Tsumura Research Inst. Pharmacology Ibaraki Jpn
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ABURADA Masaki
Central Research Laboratories, Tsumura & Co.
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ISHIGE Atsushi
Central Research Laboratories, Tsumura & Co.
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HAYAKAWA Terumasa
Central Research Laboratories, Tsumura & Co.
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KOMATSU Yasuhiro
Central Research Laboratories, Tsumura & Co.
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Ishige Atsushi
Central Research Laboratories Tsumura & Co
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油田 正樹
ツムラ研究本部 医薬評価研究所
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Komatsu Yasuhiro
Central Research Laboratories Tsumura & Co
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Hayakawa T
National Inst. Health Sci. Tokyo Jpn
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Hayakawa T
Tsumura Res. Inst. Medicinal Evaluation Lab. Ibaraki Jpn
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Hayakawa T
Central Research Laboratories Tsumura & Co.
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