釣藤鈎の研究(第1報) : 華鈎藤の科学的評価

概要

論文の詳細を見る
Hooks of Unacaria sinensis OLIV. (HAVII.) , Ka-ko-to (華鈎藤) was identified as the origin of the traditional oriental medicine, Cho-to-ko (釣藤鈎), used as a sedative, anticonvulsive and analgesic in China and Japan, by comparing the morphological and chemical characteristics of Uncaria sinensis, with those of authentic specimens. Oral administration of the chloroform soluble fraction of a MeOH extract of this material prolonged the thiopental-induced hypnotics and hypotension reaction. Of the three major indole alkaloids, geissoschizine methylether, hirsuteine and hirsutine, from this fraction, geissoschizine methylether significantly prolonged the pentobarbital-induced hypnotics at 100 mg/kg, whereas hirsuteine and hirsutine enhanced the hypotension reaction at 100 mg/kg in spontaneous hypertensive rats (SHR).
日本生薬学会の論文
1997-04-20