釣藤鈎の研究(第三報) : 鈎藤の血圧降下作用成分と抽出過程での含量変化

概要

論文の詳細を見る
Four oxindolc alkaloids, corynoxeine, rhynchophylline, isocorynoxeine and isorhynchophylline were isolated from the hooks of Gou-teng [Cho-to-kou in Japanese, the original plant Uncaria rhynchophylla (Miq.)], purchased in Jiang-xi province. Of the four alkaloids, only isorhynchophylline showed a hypotension activity in spontaneous hypertensive rats (SHR). In a water extract of the hooks, isorhynchophylline and isocorynoxeine were shown to be converted to rhynchophylline and corynoxeine within fifteen minutes, owing to the acidic condition of the extract. In one of the Cho-to-kou preparations, Diaotengsan (Cho-to-san in Japanese), the interconvertion of isorhynchophylline is retarded by the buffering action of the co-existing Shi-gao (Sekkou in Japanese).
日本生薬学会の論文
1999-12-20