アンジオテンシンI変換酵素阻害作用を有する生薬の研究(第3報) : 粉防巳中の成分およびその誘導体の活性について

概要

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Twelve bisbenzylisoquinoline (BBI) alkaloids, tetrandrine, fangchinoline, tetrandrine 2'-N-α-oxide, tetrandrine 2'-N-β-oxide, cycleahomine, 2'-N-methyltetrandrinium chloride, cycleanine, fenfangjine A, fenfangjine B, fenfangjine C, fenfangjine D, and 2,2''-N,N-dimethyltetrandrinium dichloride and two phenanthrene alkaloids, stephenanthrine and argentinine, and three benzylisoquinoline alkaloids, cyclanoline chloride, oblongine chloride, and magnoflorine chloride were isolated from a methanol extract of the root of Stephania tetrandra. In oder to clarify the structure activity relationship, 12 BBI alkaloids were tested for their inhibitory effects on angiotensin I converting enzyme. Of these isolated alkaloids, all the BBI alkaloids except cycleanine showed an inhibitory activity on angiotensin I converting enzyme.
日本生薬学会の論文
1998-04-20