Cytotoxic Effects of Mansonone E and F Isolated from Ulmus pumila(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Two sesquiterpenoids, mansonone E (ME) and mansonone F (MF) were first isolated from the dried root bark of Ulmus pumila (shironire in Japanese), and their antiproliferative activities on human tumor cells were evaluated in vitro. ME had more potent cytotoxic effects on four tumor cell lines, human cervical cancer HeLa, human malignant melanoma A375-S2, human breast cancer MCF-7, and human histiocytic lymphoma U937, than those of MF. The results showed that ME induced oligonucleosomal fragmentation of DNA in HeLa cells and activated caspase-3, followed by the degradation of the inhibitor of caspase-activated DNase, decreased the expression of anti-apoptotic mitochondrial proteins Bcl-2 and Bcl-_<XL>, and increased that of proapoptotic Bax.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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Tashiro Shin-ichi
Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn
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TASHIRO Shin-ichi
Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University
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ONODERA Satoshi
Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University
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IKEJIMA Takashi
China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Unive
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Wang Dong
中華人民共和国
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WANG Dong
Department of Radiological and Medical Laboratory Sciences
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Onodera S
Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn
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Ikejima Takashi
China-japan Res. Inst. Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univ. Chn
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Tashiro Shin-ichi
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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Onodera Satoshi
Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University
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Wang D
Kyushu Univ. Fukuoka Jpn
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Wang Dong
Department Of Pharmacognosy School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Uni
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Zhang Chun-ling
China-japan Research Institute Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univer
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Tashiro Shin-ichi
Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University
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Tashiro S
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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Onodera S
Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University
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XIA Mingyu
China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Unive
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CUI Zheng
Department of Pharmacognosy, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical U
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Xia Mingyu
China-japan Research Institute Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univer
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Wang Dong
Department Of Electronics And Mechanical Engineering Faculty Of Engineering Chiba University
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Cui Zheng
Department Of Pathology Wake Forest University School Of Medicine
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Wang Dong
Department Of Anatomy Histology And Embryology Chinese Academy Of Medical Sciences Peking Union Medi
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Xia Ming
China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University
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Ikejima Takashi
China–Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University
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Xia Mingyu
China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University
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