Evodiamine Induced Human Melanoma A375-S2 Cell Death Partially through Interleukin 1 Mediated Pathway(Pharmacology)

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概要

• 論文の詳細を見る

• We have reported that caspase cascade accompanied by the regulation of Bax/Bcl-2 and MAPK signaling were involved in evodiamine-induced A375-S2 cell death. In this study, pretreatment with interleukin 1 (IL-1) receptor antagonist (IL-1Ra) rescued the cell viability loss and reversed the ratio of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive cells induced by evodiamine. IL-1Ra was capable of attenuating the expression of Fas-ligand (Fas-L) and the cleavage of procaspas-8 and -3 caused by evodiamine. Subsequently, IL-1Ra reduced evodiamine-induced DNA degradation, p53 activation and up-regulation of Bax/Bcl-2 ratio. However, IL-1Ra attenuated the enhanced phosphorylation level of p38 mitogen-activated protein kinase (p38 MAPK) without affecting extracellular signal-regulated protein kinase (ERK) inactivation induced by evodiamine. In conclusion, IL-1-induced death cascade in melanoma A375-S2 cell might be one of the targets for natural product evodiamine, and increased Fas-L expression via IL-1 mediated pathway stands at the initiation phase, leading to consequent events that culminate in the death of the cells.

• 社団法人日本薬学会の論文
• 2005-06-01

著者

• WANG Min

  Department of Entomology, College of Natural Resources & Environment, South China Agricultural Unive

• Tashiro Shin-ichi

  Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn

• ONODERA Satoshi

  Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University

• IKEJIMA Takashi

  China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Unive

• Wang Minwei

  Department Of Pharmacology Shenyang Pharmaceutical University

• Wang Min-wei

  中華人民共和国

• Wang Min-wei

  Department Of Pharmacology Shenyang Pharmaceutical University School Of Pharmacy

• Onodera S

  Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn

• Onodera Satoshi

  昭和薬科大学 病態科

• Ikejima Takashi

  China-japan Res. Inst. Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univ. Chn

• TASHIRO Shinichi

  Department of Clinical and Biomedical Science, Showa Pharmeceutical University

• WANG Che

  China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Unive

• Wang Che

  China-japan Research Institute Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univer

• Tashiro Shin-ichi

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Onodera Satoshi

  Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University

• Tashiro Shin-ichi

  Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University

• Tashiro S

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Onodera S

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Wang Min

  Department Of Chemistry Lanzhou University

• Wang Min-wei

  Department Of Pharmacology Shen Yang Pharmaceutic University

• Wang Min

  Department Of Applied Chemistry Harbin Institute Of Technology

• Ikejima Takashi

  China–Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University

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