Organ selectivity of Juzen-taiho-to and Ninjin-yoei-to in the expression of anti-metastatic efficacy
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概要
- 論文の詳細を見る
本研究では,マウス結腸癌Colon26-L5細胞の門脈内移入により形成される肝転移および同細胞の尾静脈内移入により形成される肺転移に対する,十全大補湯および人参養栄湯の経口投与による抑制効果を検討した。十全大補湯は肝転移に対して有意に抑制したが,肺転移には抑制効果を示さなかった。これに対して,人参養栄湯は逆の効果,すなわち肝転移には効果を示さなかったが,肺転移に対して有意な抑制を示した。このように,同一の癌細胞と同系のマウスの転移病態モデルを用いて,二つの方剤の臓器選択的な転移抑制効果が観察された。このような効果発現の差異の解釈は,13世紀に確立されたtheory of Jingand Lun(引経報使)の考えに,部分的に通ずるものがあると思われる。
- 2002-06-20
著者
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SAIKI Ikuo
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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TANI Tadato
Department of Pharmacognosy
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Saiki Ikuo
Department Of Pathological Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceuti
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Tani T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Tani Tadato
Univ. Toyama Toyama Jpn
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谿 忠人
和漢薬研究所資源開発研究部門
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MATSUO Mitsuhiro
Department of Anatomy, Faculty of Medicine, University of Toyama
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済木 育夫
富山医科薬科大学
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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TANI Tadato
富山医科薬科大学和漢薬研究所資源開発部門
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Tani Tadato
Department Of Kampo Pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Tani Tadato
Department Of Kampo Pharmaceutics Institute Of Natural Medicine University Of Toyama:21^<st> C
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Tani Tadato
Department Of Kampo-pharmaceutics Institute Of Natural Medicine University Of Toyama
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Matsuo Mitsuhiro
富山大学 医学部解剖学
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Saiki Ikuo
Department Of Bioscience Institute Of Natural Medicine Toyama University
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Tani Tadato
Department Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universi
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Matsuo Mitsuhiro
Department Of Anatomy Faculty Of Medicine University Of Toyama
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