Field study and pharmaceutical evaluation of Glycyrrhiza uralensis roots cultivated in China(Material study)
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概要
- 論文の詳細を見る
rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものであるMedicinal licorice (underground parts of Glycyrrhiza plants) is an important crude drug prescribed in many traditional Chinese formulations. Recently in China, the collection of wild Glycyrrhiza plants was restricted in 1984 because it promotes desertification. With the shortage of licorice due to this restriction, there has been a demand for the cultivation of Glycyrrhiza plants. In the former half of this review, we summarized the results of our survey of the cultivation/production state of G. uralensis in China that was performed from 1998 to 2001. In China, the cultivation of G. uralensis was initiated in the early 1990s. However, the glycyrrhizin (GL) content of the cultivated roots (mainly 3-year-old roots) we collected in our survey in China did not fulfill the standard (≥2.5%) of the Japanese Pharmacopoeia (JP XIV). Such roots cannot be used for medicine in Japan. In the latter half of this review, the results of our experiments of G. uralensis cultivation in eastern Neimenggu autonomy in China were summarized. We performed cultivation from seeds of G. uralensis, and taproots were transplanted the next year. As a result, adventitious roots collected in autumn in the 4th year after seeding conformed to the JP XIV standard for GL content. This study was the first to clarify the appropriateness of G. uralensis roots cultivated in China as a resource of medicinal licorice. The anti-allergic action of the cultivated roots and their GL bioavailability after oral administration were similar to those of existing medicinal licorice prepared from wild G. uralensis in China. These results suggest that cultivated G. uralensis roots can compensate for the insufficient licorice resources. This study not only aims at the development of licorice resources and the assessment of their standards but is also a phyto-remediation study on the global environment using cultivated plants.
- 和漢医薬学会の論文
著者
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Tani T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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谿 忠人
和漢薬研究所資源開発研究部門
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山本 豊
株式会社栃本天海堂品質管理部
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TANI Tadato
Century COE program, University of Toyama
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TANI Tadato
富山医科薬科大学和漢薬研究所資源開発部門
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Yamamoto Yutaka
Department Of Breast And Endocrine Surgery Graduate School Of Medical Sciences Kumamoto University
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Tani Tadato
Department Of Kampo Pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Tani Tadato
Department Of Kampo Pharmaceutics Institute Of Natural Medicine University Of Toyama:21^<st> C
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Tani Tadato
Department Of Kampo-pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Tani Tadato
Department Of Kampo-pharmaceutics Institute Of Natural Medicine University Of Toyama
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Tani Tadato
Department Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universi
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Yamamoto Yutaka
Department Of Applied Analysis And Complex Dynamical Systems Graduate School Of Informatics Kyoto Un
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Yamamoto Yutaka
Department Of Kampo-pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Yamamoto Yutaka
Department Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universi
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