Pharmaceutical Evaluation of Glycyrrhiza uralensis Roots Cultivated in Eastern Nei-Meng-Gu of China(Pharmacognosy)
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概要
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To clarify the feasibility of medicinal use of the cultivated Glycyrrhiza resources, the equivalency between the G. uralensis roots cultivated in eastern Nei-Meng-Gu of China and medicinal licorice (Glycyrrhizae Radix, Gancao in Chinese and Kanzo in Japanese) was examined. The HPLC fingerprint including glycyrrhizin (GL) of the cultivated roots was similar to that of medicinal Gancao, but different from that of non-medicinal Xinjiang- Gancao (Shinkyo Kanzo in Japanese). Similarity between the cultivated roots and two medicinal Gancao was confirmed quantitatively by hierarchical cluster analysis on the basis of HPLC-7-peak-area data. Moreover, the 4-year-old adventitious roots conformed to the five standards described in the Japanese Pharmacopoeia XIV (JP XIV). The 4-year-old adventitious roots had similar pharmaceutical properties to those of medicinal Dongbei-Gancao (Tohoku Kanzo in Japanese) as determined by examining IgE-mediated triphasic skin reaction in mice and pharmacokinetic profile of glycyrrhetic acid, an anti-allergic metabolite of GL. The present pharmaceutical study suggests that the 4-year-old adventitious roots of G. uralensls cultivated in eastern Nei-Meng-Gu of China are comparable to medicinal Gancao conforming to the JP XIV, and may be a potential medicinal source to compensate for the insufficiency of wild Glycyrrhiza plants caused by collection restriction in China.
- 公益社団法人日本薬学会の論文
- 2003-08-01
著者
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山本 豊
株式会社栃本天海堂品質管理部
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Yamamoto Yutaka
Univ. Toyama Toyama Jpn
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Yamamoto Yutaka
Department Of Breast And Endocrine Surgery Graduate School Of Medical Sciences Kumamoto University
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Tani Tadato
Department Of Kampo Pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Tani Tadato
Department Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universi
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MAJIMA Takami
Department of Pharmacognosy, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univer
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Saiki Ikuo
Department Of Bioscience Institute Of Natural Medicine Toyama University
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Yamamoto Yutaka
Department Of Applied Analysis And Complex Dynamical Systems Graduate School Of Informatics Kyoto Un
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Yamamoto Yutaka
Department Of Kampo-pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Yamamoto Yutaka
Department Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universi
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Majima Takami
Department Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universi
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