Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-κB Signaling by Crosslinking TAK1
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概要
- 論文の詳細を見る
Several epoxyquinoids interfere with NF-κB signaling by targeting IKKβ or NF-κB. We report that epoxyquinol B (EPQB), classified as an epoxyquiniod, inhibits NF-κB signaling through inhibition of the TAK1 complex, a factor upstream of IKKβ and NF-κB. cDNA microarray analysis revealed that EPQB decreased TNF-α-induced expression of NF-κB target genes. EPQB covalently bound to a recombinant TAK1-TAB1 fusion protein in vitro, and inhibited its kinase activity. Furthermore, in vitro/in situ treatment with EPQB resulted in a ladder-like hypershift of TAK1 protein bands. We reported recently that EPQB crosslinks proteins via cysteine residues by opening its two epoxides, and our current results suggest that EPQB inhibits NF-κB signaling by crosslinking TAK1 itself or TAK1 through other proteins.
- 社団法人 日本農芸化学会の論文
著者
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OSADA Hiroyuki
Antibiotics Laboratory, Discovery Research institute, RIKEN
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HAYASHI Yujiro
Department of Human and Mechanical Systems Engineering, Kanazawa Univ.
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SHOJI Mitsuru
Department of Chemistry, Graduate School of Science, Tohoku University
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KAKEYA Hideaki
Antibiotics Laboratory, RIKEN
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KAMIYAMA Hiroshi
Antibiotics Laboratory, RIKEN Discovery Research Institute
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Usui Takeo
Graduate School of Life and Environmental Sciences, University of Tsukuba
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Sakurai Hiroaki
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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