Biotransformation of the Mycotoxin, Zearalenone, to a Non-estrogenic Compound by a Fungal Strain of Clonostachys sp.(Organic Chemistry)

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概要

• 論文の詳細を見る

• Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1- (3, 5-dihydroxyphenyl) -10' -hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17 β-estradiol in the human breast cancer MCF-7 cell proliferation assay.

• 社団法人日本農芸化学会の論文
• 2002-12-23

著者

• OSADA Hiroyuki

  Antibiotics Laboratory, Discovery Research institute, RIKEN

• KIMURA Makoto

  Laboratory of Structural Biology, Graduate School of Systems Life Sciences, Kyushu University

• Osada H

  Antibiotics Laboratory Advanced Science Institute Riken

• Onose R

  Riken Saitama Jpn

• Yamaguchi I

  Department Of Applied Biological Chemistry The University Of Tokyo

• TAKAHASHI-ANDO Naoko

  Laboratory for Remediation Research, Plant Science Center, RIKEN

• YAMAGUCHI Isamu

  Laboratory for Remediation Research, Plant Science Center, RIKEN

• KAKEYA Hideaki

  Antibiotics Laboratory, RIKEN

• Kimura M

  Laboratory Of Biochemistry Faculty Of Agriculture Graduate School Kyushu University

• Yamaguchi I

  Microbial Toxicology Laboratory Riken:(present Address)environmental Plant Research Group Plant Scie

• Yamaguchi Isamu

  Laboratory For Remediation Research Plant Science Center Riken

• Yamaguchi I

  Riken The Institute Of Physical And Chemical Research

• ONOSE Rie

  Antibiotics Laboratory, RIKEN

• Yamaguchi Isomaro

  Department Of Applied Biological Chemistry University Of Tokyo

• Osada Hiroyuki

  Antibiotics Laboratory Advanced Science Institute Riken

• Onose Rie

  Antibiotics Laboratory Riken

• Osada Hiroyuki

  Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)

• Kakeya H

  Antibiotics Laboratory Advanced Science Institute Riken

• Kimura Makoto

  Plant & Microbial Metabolic Engineering Research Unit Discovery Research Institute (dri) Riken

• Mimori Kouhei

  Laboratory For Remediation Research Plant Science Center Riken:department Of Engineering Toyo Univer

• Kakeya Hideaki

  Department Of' Chemistry Keio University

• Kakeya H

  Riken Saitama Jpn

• Kakeya Hideaki

  Antibiotics Laboratory Advanced Science Institute Riken

• Yamaguchi I

  Riken (the Institute Of Physical And Chemical Research) Plant Science Center

• Kimura Makoto

  Laboratory Of Biochemistry Department Of Bioscience And Biotechnology Graduate School Faculty Of Agr

• Yamaguchi Isamu

  Laboratory For Remediation Research Environmental Plant Research Group Plant Science Center Riken In

• Kimura Makoto

  Laboratory Of Biochemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture Graduat

• Kimura Makoto

  Laboratory Of Biochemistry Department Of Agricultural Chemistry Faculty And Graduate School Of Agric

• KIMURA Makoto

  Plant & Microbial Metabolic Engineering Research Unit, Discovery Research Institute (DRI), RIKEN

• KIMURA Makoto

  Laboratory for Remediation Research, Plant Science Center, RIKEN

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