New Pyrrolobenzodiazepine Antibiotics, RK-1441A and B : I. Biological Properties(Organic Chemistry)
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概要
- 論文の詳細を見る
Streptomyces griseus and bacteriophage B were used for an assay system detecting anti-bacteriophage antibiotics. Streptomyces sp. RK-1441 was found to produce antibacteriophage anti-biotics, RK-1441 A and B, which are pyrrolo[1,4]benzodiazepine group antibiotics related to neo-thramycin. Both RK-1441 A and B had antibacteriophage activity. The former showed antimicrobial activity on a hypersensitive strain of E. coli for antitumor antibiotics, but the later did not show the activity. Restriction enzyme assay suggested that RK-1441 A formed adducts with guanine residues in DNA strands. RK-1441 B was not active in vitro, but it might be converted to the active form in host organisms.
- 社団法人日本農芸化学会の論文
- 1990-11-23
著者
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OSADA Hiroyuki
Antibiotics Laboratory, Discovery Research institute, RIKEN
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Isono K
Inst. Physical And Chemical Res. Saitama Jpn
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Isono Kiyoshi
理化学研究所
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Osada H
Antibiotics Laboratory Advanced Science Institute Riken
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KAJIKAWA Kaichiro
Ageo Seiken
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ISHINABE Ken
Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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YANO Tatsuya
Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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ISONO Kiyoshi
Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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Isono K
Department Of Marine Science School Of Marine Science And Technology Tokai University
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Isono Kiyoshi
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research)
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Isono Kiyoshi
The Institute Of Physical And Chemical Research(riken)
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Isono Kiyoshi
Riken The Institute Of Physical And Chemical Research
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Osada Hiroyuki
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Ishinabe Ken
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research)
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Yano Tatsuya
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research)
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Kobinata K
Antibiotics Laboratory The Institute Of Physical And Chemical Research (riken)
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Yano T
Univ. Tokyo Tokyo Jpn
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