Identification and Characterization of an Inhibitor of Trichothecene 3-O-Acetyltransferase, TRI101, by the Chemical Array Approach
スポンサーリンク
概要
- 論文の詳細を見る
Trichothecene 3-O-acetyltransferase (TRI101) is an indispensable enzyme for the biosynthesis of trichothecenes, a group of mycotoxins produced by Fusarium graminearum. In this study, an inhibitor of TRI101 was identified by chemical array analysis using compounds from the RIKEN Natural Products Depository (NPDepo) library. Although the addition of the identified enzyme inhibitor to the fungal culture did not inhibit trichothecene production, it can serve as a candidate lead compound in the development of a mycotoxin inhibitor that inactivates fungal defense mechanisms.
著者
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Osada Hiroyuki
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Kimura Makoto
Department Of Applied Biochemistory Utsunomiya University
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Yoshida Minoru
Chemical Genetics Laboratory Advanced Science Institute (asi) Riken
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Yamamoto Takeshi
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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Kobayashi Tetsuo
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
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Kimura Makoto
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
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KOBAYASHI Tetsuo
Department of Anatomy II
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OJIMA Teruyo
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
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SABURI Wataru
Antibiotics Laboratory/Global Research Cluster, RIKEN Center for Sustainable Resource Science
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ICHIKAWA Hinayo
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
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MOTOYAMA Takayuki
Antibiotics Laboratory/Global Research Cluster, RIKEN Center for Sustainable Resource Science
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KONDOH Yasumitsu
Antibiotics Laboratory/Global Research Cluster, RIKEN Center for Sustainable Resource Science
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SAITO Tamio
Antibiotics Laboratory/Global Research Cluster, RIKEN Center for Sustainable Resource Science
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MAEDA Kazuyuki
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
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