Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

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概要

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• Epoxyquinol B (EPQB) is a fungal metabolite, containing two ???-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues of receptor kinases. However, the inhibitory mechanism was undefined. In this report, we found that one EPQB molecule is covalently bound to two L-cysteine molecules through two epoxide residues on EPQB. Furthermore, EPQB crosslinked binding proteins through the cysteine residues. These results suggest that EPQB inhibits receptor kinases by crosslinking with other protein or by intramolecular crosslinking.

• 財団法人日本抗生物質学術協議会の論文
• 2008-02-25

著者

• Uramoto Masakazu

  Antibiotics Laboratory Chemical Biology Department Riken Asi

• Hiroshi TAKAGI

  Antibiotics Laboratory, RIKEN Discovery Research Institute

• Osada Hiroyuki

  Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)

• Shoji Mitsuru

  Department Of Chemistry Graduate School Of Science Tohoku University

• Kakeya Hideaki

  Antibiotics Laboratory Advanced Science Institute Riken

• Hayashi Yujiro

  Department Of Chemistry Faculty Of Science The University Of Tokyo

• KAKEYA Hideaki

  Antibiotics Laboratory, RIKEN Discovery Research Institute

• 神山 洋

  Antibiotics Laboratory, RIKEN Discovery Research Institute

• 長田 裕之

  Antibiotics Laboratory, RIKEN Discovery Research Institute

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