Asymmetric Reactions of Enamines with Methyl(E)-4-Oxo-4-(2-oxo-1,3-oxazolidin-3-yl)-2-butenoate by the Use of a Chiral Titanium Reagent.
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概要
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Asymmetric Michael and [2+2] cycloaddition reactions between enamines and methyl (<I>E</I>)-4-oxo-4-(2-oxo-1,3-oxazolidin-3-yl)-2-butenoate proceed with a chiral titanium reagent generated in situ from dichlorodiisopropoxytitanium and a tartrate-derived chiral 1,4-diol. In the presence of excess amounts of the chiral titanium reagent, good to moderate enantioselectivity is attained. The reactions are also well catalyzed even with a catalytic amount of the titanium reagent.
- 公益社団法人 日本化学会の論文
著者
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Narasaka Koichi
Department Of Applied Chemistry Faculty Of Engineering Kyushu Institute Of Technology
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Hayashi Yujiro
Department Of Chemistry Faculty Of Science The University Of Tokyo
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SAITO Nobuo
Department of Chemistry, Graduate School of Science, The University of Tokyo
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Otaka Ken
Department of Chemistry, Faculty of Science, The University of Tokyo
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