A Chemo-Enzymatic Expeditious Route to Racemic Dihexanoyl (2R*,3R*,4R*)-Dehydroxymethylepoxyquinomycin (DHMEQ), the Precursor for Lipase-Catalyzed Synthesis of the Potent Nuclear Factor-κB Inhibitor, (2S,3S,4S)-DHMEQ
スポンサーリンク
概要
- 論文の詳細を見る
In order to synthesize the potent nuclear factor (NF)-κB inhibitor, (2S,3S,4S)-dehydroxymethylepoxyquinomycin (DHMEQ), in a large scale, a new route for its corresponding racemic precursor, dihexanoyl (2R*,3R*,4R*)-DHMEQ, was developed. By employing both hydroquinone and benzoquinone intermediates, the total yield, reproducibility, and synthetic steps were improved and the synthetic cost was reduced.
著者
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Shoji Mitsuru
Department Of Chemistry Graduate School Of Science Tohoku University
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Kobayashi Ryohei
Department Of Electrical And Electronic Engineering Nagoya Institute Of Technology
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Sugai Takeshi
Department Of Agricultural Chemistry The University Of Tokyo
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Sugai Takeshi
Department of Pharmaceutical Science, Keio University
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Umezawa Kazuo
School of Medicine, Aichi Medical University
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Hanaya Kengo
Department of Pharmaceutical Science, Keio University
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Shoji Mitsuru
Department of Pharmaceutical Science, Keio University
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Kobayashi Ryohei
Department of Pharmaceutical Science, Keio University
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