Synthesis of Regioselectively Protected Forms of Cytidine Based on Enzyme-catalyzed Deacetylation as the Key Step

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概要

• 論文の詳細を見る

• N^4-Acetylcytidine (77%) and 2', 3'-O, N^4-triacetyl-cytidine (95%) were obtained from the hydrolysis of a common precursor, the peracetylated form of cytidine with Aspergillus niger lipase (Amano A) and Burkholderia cepacia esterase (SC esterase S), respectively, under very mild conditions. The experimental procedure for the conversion of triacetylcytidine to a corresponding phosphoramidite (82%), an intermediate for sugar nucleotide synthesis, is also elaborated.

• 社団法人日本農芸化学会の論文
• 2000-02-23

著者

• 須貝 威

  慶應義塾大学理工学部

• MIYAZAKI Tatsuo

  Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences

• Ohta H

  Okayama Univ. Okayama

• Ohta H

  Department Of Bioscience And Informatics Center For Life Science And Technology Keio University

• Ohta H

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Ohta H

  Department Of Chemistry Keio University

• Ohta Hiromichi

  Department Of Chemistry Faculty Of Science And Technology Keio University

• ISHIHARA Takashi

  Department of Computational Science and Engineering, Graduate School of Engineering, Nagoya Universi

• Kobayashi Eiko

  Department Of Chemistry Keio University

• Ohta H

  Keio Univ. Kanagawa

• Sugai Tomoharu

  Department Of Bioresource Engineering Faculty Of Agriculture Yamagata University

• SUGAI Takeshi

  Department of Chemistry, Faculty of Science and Technology, Keio University

• KUBOKI Atsuhito

  Department of Chemistry, Keio University

• Kajihara Yasuhiro

  Department Of System Function Faculty Of Science Yokohama City University

• Kajihara Yasuhiro

  Department Of System Function Yokohama City University

• ISHII Takeshi

  Biotechnology Laboratory, Sumitomo Chemical Co. Ltd.

• INOUE Ayumu

  Biotechnology Laboratory, Sumitomo Chemical Co. Ltd.

• MITSUDA Satoshi

  Biotechnology Laboratory, Sumitomo Chemical Co. Ltd.

• Ohta H

  Department Of Food And Nutrition Nakamura Gakuen University

• Ohta Hiromichi

  Department Of Applied Chemistry School Of Engineering Nagoya University

• Inoue Ayumu

  Biotechnology Laboratory Sumitomo Chemical Co. Ltd.

• Inoue Ayumu

  Biotechnology Laboratory Sumitomo Chemical Co.

• Okazaki Hanako

  Department Of Chemistry Keio University

• Kuboki Atsuhito

  Department Of Chemistry Keio University

• Kuboki Atsuhito

  Department Of Biochemistry Okayama University Of Science

• Mitsuda Satoshi

  Biotechnology Laboratory Sumitomo Chemical Co. Ltd.

• Sugai Takeshi

  Department Of Agricultural Chemistry The University Of Tokyo

• Miyazaki T

  Department Of System Function Yokohama City University

• Ishihara Takashi

  Department Of Cardiovascular Medicine Tokyo Medical And Dental University

• Miyazaki Tatsuo

  Department Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences

• Ishii Takeshi

  Biotechnology Laboratory Sumitomo Chemical Co. Ltd.

• Kajihara Yasuhiro

  Department Of Chemistry Osaka University

• Ishihara Takashi

  Department Of Chemistry Keio University

• Ishihara Takashi

  Department Of Applied Physics Nagoya University

• Kajihara Yasuhiro

  Department Of Chemistry Graduate School Of Science Osaka University

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