Production of Ethyl (R)-2-Hydroxy-4-phenylbutanoate via Reduction of Ethyl 2-Oxo-4-phenylbutanoate in an Interface Bioreactor

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概要

• 論文の詳細を見る

• Ethyl (R)-2-hydroxy-4-phenylbutanoate [(R)-EHPB], a useful intermediate for the synthesis of various anti-hypertension drugs, was produced via microbial reduction of ethyl 2-oxo-4-phenylbutanoate [EOPB] in an interface bioreactor. Rhodotorula minuta IFO 0920 and Candida holmii KPY 12402 were selected as the best type culture and isolated yeasts, respectively. The highest enantiomeric excess of (R)-EHPB produced by R. minuta and C. holmii were 95 and 94%, respectively. C. holmii was used for the reduction of EOPB in a pad-packed interface bioreactor (inner volume, 3 liter). After incubation for 4 days, 4.4 g of (R)-EHPB was obtained via extraction with methanol followed by column chromatography. The overall yield, chemical purity, and enantiomeric excess of (R)-EHPB were 58%, 99.1%, and 90%, respectively.

• 社団法人日本農芸化学会の論文
• 1998-09-23

著者

• Oda S

  Analytical Center Kansai Paint Co. Ltd.

• Oda S

  Kansai Paint Co. Ltd. Kanagawa Jpn

• Oda Shinobu

  Technical Research Laboratory Kansai Paint Co. Ltd.

• Ohta H

  Okayama Univ. Okayama

• Ohta H

  Department Of Bioscience And Informatics Center For Life Science And Technology Keio University

• Ohta H

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Ohta H

  Department Of Chemistry Keio University

• Ohta Hiromichi

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Ohta H

  Keio Univ. Kanagawa

• Ohta H

  Department Of Food And Nutrition Nakamura Gakuen University

• Ohta Hiromichi

  Department Of Applied Chemistry School Of Engineering Nagoya University

• INADA Yuichi

  Department of Chemistry, Faculty of Science and Technology, Keio University

• KOBAYASHI Atsuko

  Department of Chemistry, Faculty of Science and Technology, Keio University

• Inada Yuichi

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Okazaki Hanako

  Department Of Chemistry Keio University

• Kobayashi Atsuko

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Kobayashi Atsuko

  Department Of Anesthesiology And Intensive Care Saiseikai Suita Hospital

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