Degradation of Derivatives of N-Acetyl-D-glucosamine by Rhodococcus rhodochrous IFO 15564 : Substrate Specificity and Its Application to the Synthesis of Allyl α-N-Acetyl-D-glucosaminide

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概要

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• The substrate specificity was studied for the metabolic degradation of N-acetyl-D-glucosamine (GlcNAc) derivatives by Rhodococcus rhodochrous IFO 15564 which possesses N-acetyl-D-glucosamine deacetylase as a key-step enzyme. This microorganism degraded a wide range of substrates with modified N-acyl groups. The metabolizing activity of this strain became low to the substrates substituted at 1,3,4,6-positions of GlcNAc, and GlcNAc itself was suggested to be metabolized via an open-chain aldehyde form. Based on these results, a simplified procedure for the isolation of allyl α-N-acetyl-D-glucosaminide from an α, β-anomeric mixture was developed by selectively hydrolyzing the β-anomer with Jackbean β-N-acetyl-D-glucosaminidase and subsequently degrading the resulting N-acetyl-D-glucosamine in the reaction mixture with this microorganism.

• 社団法人日本農芸化学会の論文
• 1998-08-23

著者

• 須貝 威

  慶應義塾大学理工学部

• Ohta H

  Okayama Univ. Okayama

• Ohta H

  Department Of Bioscience And Informatics Center For Life Science And Technology Keio University

• Ohta H

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Ohta H

  Department Of Chemistry Keio University

• Ohta Hiromichi

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Ohta H

  Keio Univ. Kanagawa

• Sugai Tomoharu

  Department Of Bioresource Engineering Faculty Of Agriculture Yamagata University

• SUGAI Takeshi

  Department of Chemistry, Faculty of Science and Technology, Keio University

• KUBOKI Atsuhito

  Department of Chemistry, Keio University

• Sekiguchi Takahiro

  Department Of Chemistry Keio University

• KOMIYA Ryosuke

  Department of Chemistry, Keio University

• KATSURAGI Kenji

  Department of Chemistry, Keio University

• Ohta H

  Department Of Food And Nutrition Nakamura Gakuen University

• Ohta Hiromichi

  Department Of Applied Chemistry School Of Engineering Nagoya University

• Komiya Ryosuke

  Department Of Chemistry Keio University

• Okazaki Hanako

  Department Of Chemistry Keio University

• Kuboki Atsuhito

  Department Of Chemistry Keio University

• Kuboki Atsuhito

  Department Of Biochemistry Okayama University Of Science

• Sugai Takeshi

  Department Of Agricultural Chemistry The University Of Tokyo

• Katsuragi Kenji

  Department Of Chemistry Keio University

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