Optical Resolution of Racemic Citronellol via a Double Coupling System in an Interface Bioreactor
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概要
- 論文の詳細を見る
A double coupling system consisting of acetyl coenzyme A[acetyl-CoA]formation via the metabolism of glucose and the subsequent acetylation of a primary alcohol by acetyl-CoA with the aid of alcohol acetylfransferase[AATFase], was applied for the optical resolution of racemic citronellol. Pichia kluyveri IFO 1165 was superior for the optical resolution of racemic citronellol and provided (S)-citronellyl acetate and (R)-citronellol with high enantioselectivity and yield. The strain also exhibited excellent resistance to high concentrations of citronellol, i.e., it could maintain metabolism and enantioselective acetylation even in the presence of 30% citronellol. The coupling system using P.kluyveri IFO 1165 was applied to two new types of interface bioreactors, tentatively referred to as bead-packed and multistory interface bioreactors. Using the latter bioreactor, (S)-citronellyl acetate and(R)-citronellol were produced in large amounts at high enantioselectivity and yield.
- 社団法人日本生物工学会の論文
- 1999-04-25
著者
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須貝 威
慶應義塾大学理工学部
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Oda S
Analytical Center Kansai Paint Co. Ltd.
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Oda S
Kansai Paint Co. Ltd. Kanagawa Jpn
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Oda Shinobu
Technical Research Laboratory Kansai Paint Co. Ltd.
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Ohta H
Okayama Univ. Okayama
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Ohta H
Department Of Bioscience And Informatics Center For Life Science And Technology Keio University
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Ohta H
Department Of Chemistry Faculty Of Science And Technology Keio University
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Ohta H
Department Of Chemistry Keio University
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Ohta H
Keio Univ. Kanagawa
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Sugai Tomoharu
Department Of Bioresource Engineering Faculty Of Agriculture Yamagata University
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Ohta H
Department Of Food And Nutrition Nakamura Gakuen University
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SUGAI TAKESHI
the Department of Chemistry, Faculty of Science and Technology, Keio University
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OHTA HIROMICHI
the Department of Chemistry, Faculty of Science and Technology, Keio University
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Okazaki Hanako
Department Of Chemistry Keio University
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