Short-Step and Scalable Synthesis of (±)-Cytoxazone

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概要

• 論文の詳細を見る

• A five-step and scalable synthesis of racemic cytoxazone, a novel cytokine modulator, was accomplished in a total yield of 51% from p-methoxycinnamyl alcohol without any protective groups. The keystep was the new one-pot azidohydroxylation procedure by the combined use of NaN3–H2O2–CH3CN. The epoxidation of an olefin by means of an in situ-formed iminohydroperoxide worked well, accompanied by the concomitant regioselective ring opening reaction of the resulting highly reactive epoxide with an azide ion.

• 社団法人 日本農芸化学会の論文
• 2005-01-23

著者

• SUGAI Takeshi

  Department of Chemistry, Faculty of Science and Technology, Keio University

• NISHIYAMA Shigeru

  Department of Chemistry, Faculty of Science and Technology, Keio University

• Nishiyama Shigeru

  Department Of Chemistry Faculty Of Science And Technology Keio University

• Suzuki Masumi

  Department Of Chemistry Keio University

• Sugai Takeshi

  Department Of Agricultural Chemistry The University Of Tokyo

• ASANO Masayoshi

  Department of Chemistry, Keio University

• NAGASAWA Chiaki

  Department of Chemistry, Keio University

• Nishiyama S

  Department Of Chemistry Keio University

• Asano Masayoshi

  Department Of Chemistry Keio University

• Nagasawa Chiaki

  Department Of Chemistry Keio University

• Nishiyama Shigeru

  Department Of Chemistry Faculty Of Science And Technology Keio Univerisity

• Nishiyama Shigeru

  Department of Applied Chemistry, Faculty of Engineering, Keio University

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