Reductive C_2-Homologation of Substituted Benzaldehydes by Fermenting Baker's Yeast(Organic Chemistry)
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概要
- 論文の詳細を見る
Reduction of benzaldehyde and substituted benzaldehydes with actively fermenting baker's yeast afforded optically active 1-arylpropane-1,2-diols in fairly good yields, as well as benzylic alcohols. It was revealed that benzaldehydes substituted with electron-withdrawing groups, which were previously reported to result only corresponding benzylic alcohols, were also reduced to give propanediol compounds in moderate yields. The reaction was shown to be highly diastereo-selective for erythro diols (>97% d.e.). The optical purities of the erythro isomers (1R,2S) were also extremely high (>91% e.e.), and single recrystallization of dibenzoates gave optically pure diol derivatives within the limits of HPLC analysis.
- 社団法人日本農芸化学会の論文
- 1986-05-23
著者
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Okamoto Kazuyuki
Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Faculty Of Agriculture Yamag
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Ohta Hiromichi
Department Of Chemistry Faculty Of Science And Technology Keio University
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Tsuchihashi Gen-ichi
Department of Chemistry, Keio University
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Ohta Hiromichi
Department Of' Chemistry Keio University
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OZAKI Kazuhiko
Department of Chemistry, Faculty of Science and Technology, Keio University
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KONISHI Jin
Department of Chemistry, Faculty of Science and Technology, Keio University
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Ohta H
Keio Univ. Yokohama Jpn
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Ohta Hiromichi
Department Of Applied Chemistry School Of Engineering Nagoya University
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Konishi Jin
Department Of Chemistry Faculty Of Science And Technology Keio University
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Okamoto Kikuhiko
Research Institute Of Food Science School Of Medicine Kinki University
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Ozaki Kazuhiko
Department Of Chemistry Faculty Of Science And Technology Keio University
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Tsuchihashi G
Keio Univ. Yokohama Jpn
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Tsuchihashi Gen-ichi
Department Of Chemistry Faculty Of Science And Technology Keio University
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