Intrarenal Localization of Receptors for α-Rat Atrial Natriuretic Polypeptide: An Autoradiographic Study with [<SUP>125</SUP>I]-Labeled Ligand Injected in Vivo into the Rat Aorta
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概要
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We examined intrarenal localization of receptors for α-rat atrial natriuretic polypeptide (α-rANP) by injecting [<SUP>125</SUP>I]-labeled ligand in vivo into the rat aorta. We found that the receptors for α-rANP are distributed also on the vasa recta of the outer and inner medulla in addition to the previously reported sites, i.e., the renal arteries, renal pelvis, glomeruli, and inner medullary tissues including collecting tubules. In the vascular bundle of the outer medulla, the majority of grains was preferentially localized on the arterial vasa recta. The electron microscopic autoradiography of the glomerulus showed that the binding sites were mainly localized on the foot process of the podocyte. Since α-rANP injected into the aorta under physiological conditions was bound to the glomerulus and vasa recta in the kidney, the effect of ANP on these binding sites may be important in the mechanism of natriuresis.
著者
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Ohnuma Norio
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences University Of Tokyo:laboratory Of Cli
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Imai Masashi
Department Of Pharmacology Division Of Molecular Pharmacology Jichi Medical University
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Koseki Chizuko
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
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KANAI YASUSHI
Department of Information and Electronics Engineering, Niigata Institute of Technology
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Hayashi Yujiro
Department Of Chemistry Faculty Of Science The University Of Tokyo
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IMAI Masashi
Department of Pharmacology, National Cardiovascular Center Research Institute
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OHNUMA Norio
Department of Clinical Pharmacology, Suntory Institute for Biomedical Research
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HAYASHI Yujiro
Department of Clinical Pharmacology, Suntory Institute for Biomedical Research
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KANAI Yasushi
Department of Clinical Pharmacology, Suntory Institute for Biomedical Research
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KOSEKI Chizuko
Department of Pharmacology, National Cardiovascular Center Research Institute
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