Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B

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概要

• 論文の詳細を見る

• We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.

• 社団法人日本農芸化学会の論文
• 2001-03-23

著者

• OSADA Hiroyuki

  Antibiotics Laboratory, Discovery Research institute, RIKEN

• Osada H

  Riken Inst. Saitama Jpn

• Ahn Jong-seog

  Cellular Response Modifier Research Unit Korea Research Institute Of Bioscience And Biotechnology

• Ko Hack-ryong

  Antibiotics Laboratory Riken:cellular Response Modifier Research Unit Korea Research Institute Of Bi

• Osada Hiroyuki

  Antibiotics Laboratory Riken

• Kusama Takehiko

  Department Of Aquatic Biosciences Tokyo University Of Fisheries

• TOGASHI Ken-ichi

  Antibiotics Laboratory, RIKEN

• Togashi Ken-ichi

  Graduate School Of Science Technology Niigata University

• Togashi Ken-ichi

  Antibiotics Laboratory Riken:(present Address) Laboratory Animal Research Center Institute Of Medica

• Osada Hiroyuki

  Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)

• Ahn Jong-Song

  Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology

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