Morphological Changes of Human Myeloid Leukemia K562 Cells by a Protein Phosphatase Inhibitor, Tautomycin
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概要
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An antibiotic, tautomycin induced bled formation and protein phosphorylation of K562 cells as do the protein phosphatase inhibitors, okadaic acid and dinophysistoxin-1. Tautomycin inhibited the specific binding of [3H]okadaic acid to protein phosphatases. Furthermore, tautomycin inhibited the protein phosphatases isolated from mouse brain. However, tautomycin did not activate the protein kinase C. These results indicate that tautomycin induces bled formation through inhibition of protein phosphatases.
著者
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MAGAE Junji
Department of Bioengineering, Tokyo Institute of Technology
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YAMASAKI Makari
Laboratory of Microbiology, Department of Agricultural Chemistry, University of Tokyo
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Nagai Kazuo
Department Of Applied Biological Chemistry Chubu University
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Isono Kiyoshi
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research)
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Osada Hiroyuki
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Suzuki Koichi
Department Of Agro-bioscience Faculty Of Agriculture Iwate University
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Saido Takaomi
Department Of Molecular Biology The Tokyo Metropolitan Institut Of Medical Science
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ISONO Kiyoshi
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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FUJIKI Hirota
Cancer Prevention Division, National Cancer Center Research Institute
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OSADA Hiroyuki
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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SUZUKI Koichi
Department of Molecular Biology, The Tokyo Metropolitan Institute of Medical Science
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