Chemical Modification of Cationomycin and Its Structure-Activity Relationship(Organic Chemistry)
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概要
- 論文の詳細を見る
Chemical modification of a polyether ionophore antibiotic, cationomycin, was attempted to clarify the structure-activity relationship and to obtain derivatives with higher activity. Deacylcationomycin showed the same ion selectivity as the parent compound, but it was less effective in sodium ion transport and anticoccidial activity. Thirteen acyl or alkyl derivatives were prepared by regioselective reactions. No derivatives were more effective in sodium ion transport. There are apparent relationships between sodium ion transport of acetyl derivatives and their biological activities.
- 社団法人日本農芸化学会の論文
- 1986-05-23
著者
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ISONO Kiyoshi
Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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UBUKATA Makoto
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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Isono Kiyoshi
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research)
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HAMAZAKI Yasuhiko
Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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Hamazaki Yasuhiko
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research):(present Office)kakke
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Ubukata Makoto
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research)
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