Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation
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概要
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Epoxyquinol B (EPQB) is a fungal metabolite, containing two ???-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues of receptor kinases. However, the inhibitory mechanism was undefined. In this report, we found that one EPQB molecule is covalently bound to two L-cysteine molecules through two epoxide residues on EPQB. Furthermore, EPQB crosslinked binding proteins through the cysteine residues. These results suggest that EPQB inhibits receptor kinases by crosslinking with other protein or by intramolecular crosslinking.
- 財団法人日本抗生物質学術協議会の論文
- 2008-02-25
著者
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OSADA Hiroyuki
Antibiotics Laboratory, Discovery Research institute, RIKEN
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Uramoto Masakazu
Antibiotics Laboratory Chemical Biology Department Riken Asi
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Usui Takeo
Antibiotics Laboratory Riken Discovery Research Institute
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HAYASHI Yujiro
Department of Human and Mechanical Systems Engineering, Kanazawa Univ.
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SHOJI Mitsuru
Department of Chemistry, Graduate School of Science, Tohoku University
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Uramoto Masakazu
Antibiotics Laboratory Riken Discovery Research Institute
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KAKEYA Hideaki
Antibiotics Laboratory, RIKEN
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KAMIYAMA Hiroshi
Antibiotics Laboratory, RIKEN Discovery Research Institute
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Hiroshi TAKAGI
Antibiotics Laboratory, RIKEN Discovery Research Institute
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Osada Hiroyuki
Antibiotics Laboratory Riken Discovery Research Institute
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