Actin Stress Fiber Retraction and Aggresome Formation Is a Common Cellular Response to Actin Toxins
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概要
- 論文の詳細を見る
F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins.
- 社団法人 日本農芸化学会の論文
- 2011-09-23
著者
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Usui Takeo
Antibiotics Laboratory Riken Discovery Research Institute
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Osada Hiroyuki
Chemical Biology Dep. Riken Advanced Sci. Inst.
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Kazami Sayaka
Antibiotics Laboratory Riken Discovery Research Institute
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Usui Takeo
Chemical Library And Bioprobe Res. Group Riken Advanced Sci. Inst.
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Osada Hiroyuki
Antibiotics Laboratory Riken Discovery Research Institute
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Kazami Sayaka
Chemical Library Validation Team Chemical Biology Core Facility Riken Advanced Science Institute
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Usui Takeo
Graduate School Of Life And Environmental Sciences Univ. Of Tsukuba
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Osada Hiroyuki
Chemical Biology Core Facility Chemical Biology Department Riken Advanced Science Institute
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