Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

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概要

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• Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

• 社団法人 日本農芸化学会の論文

著者

• Kiyota Hiromasa

  Graduate School of Agricultural Science, Tohoku University

• Saito Tamio

  Chemical Library Management And Informatics Team Advanced Science Institute Riken

• Usui Takeo

  Chemical Library And Bioprobe Res. Group Riken Advanced Sci. Inst.

• SATO Yuuki

  Graduate School of Agricultural Science, Tohoku University

• KAMIYAMA Hiroshi

  Graduate School of Science and Engineering, Saitama University

• OSADA Hiroyuki

  Graduate School of Science and Engineering, Saitama University

• KUWAHARA Shigefumi

  Graduate School of Agricultural Science, Tohoku University

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