Epiderstatin Induces the Flat Reversion of NRK Cells Transformed by Temperature-sensitive Rous Sarcoma Virus
スポンサーリンク
概要
- 論文の詳細を見る
Epiderstatin is a unique glutarimide antibiotic which was found by screening for inhibitors of the signal transduction of epidermal growth factor (EGF). The antibiotic (0.01 μM) was found to reverse the morphology of NRK cells that were infected with a temperature-sensitive mutant of Rous sarcoma virus (src^<ts>-NRK) from the transformed phenotype to the normal phenotype at the permissive temperature (32℃). Epiderstatin did not inhibit the protein kinase activity of p60^<v-src>. The cell cycle progression of src^<ts>-NRK cells was blocked at G0/G1 phase, which was caused by the inhibition of biosynthesis of p60^<v-src> but not the transcription of v-src mRNA.
- 社団法人日本農芸化学会の論文
- 1992-11-23
著者
-
Isono K
Inst. Physical And Chemical Res. Saitama Jpn
-
Osada H
Antibiotics Laboratory Advanced Science Institute Riken
-
OSADA Hiroyuki
The Institute of Physical and Chemical Research (RIKEN)
-
ISONO Kiyoshi
The Institute of Physical and Chemical Research, RIKEN
-
SASAKI Mutsumi
The Institute of Physical and Chemical Research (RIKEN)
-
SONODA Tadamichi
The Institute of Physical and Chemical Research (RIKEN)
-
Isono K
The Institute Of Physical And Chemical Research Riken
-
Isono Kiyoshi
The Institute Of Physical And Chemical Research
-
Isono Kiyoshi
The Institute Of Physical And Chemical Research(riken)
-
Isono Kiyoshi
The Institute Of Physical And Chemical Research (riken):(present Address) Department Of Marine Scien
-
Sonoda Tadamichi
The Institute Of Physical And Chemical Research (riken):(present Address) Riken Vitamin Co. Ltd.
-
SONODA TOMOHIKO
Amase Institute, Hayashibara Biochemical Laboratories, Inc.
-
Isono K
Tokai Univ. Shimizu Jpn
関連論文
- Morphological Changes and Reorganization of Actinfilaments in Human Myeloid Leukemia Cells Induced by a Novel Protein Phosphatase Inhibitor, Tautomycin
- Liposidomycin Binhibits In Vitro Formation of Polyprenyl(pyro)phosphate N-Acetylglucosamine, an Intermediate in Glycoconjugate Biosynthesis
- Lucilactaene, a New Cell Cycle Inhibitor in p53-Transfected Cancer Cells, Produced by a Fusarium sp.
- New Types of Liposidomycins Which Inhibit Bacterial Peptidoglycan Synthesis Produced by Streptomyces
- Selective Inhibition of the Bacterial Peptidoglycan Biosynthesis by the New Types of Liposidomycins
- New Types of Liposidomycins that Inhibit Bacterial Peptidoglycan Synthesis and are Produced by Streptomyces II. Isolation and Structure Elucidaion
- New Types of Liposidomycins that Inhibit Bacterial Peptdoglycan Synthesis and are Produced by Streptomyces I. Producing Organism and Medium Components
- Acetophthalidin, a Novel Inhibitor of Mammalian Cell Cycle, Produced by a Fungus Isolated from a Sea Sediment
- Structure-Activity Relationship within a Series of Degradation Products of Tautomycin
- Tryprostatins A and B, Novel Mammalian Cell Cycle Inhibitors Produced by Aspergillus fumigatus
- Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus
- RS-22A, B and C:New Macrolide Antibiotics from Streptomyces violaceusniger I.Taxonomy, Fermentation, Isolation and Biological Activities
- Epiderstatin Induces the Flat Reversion of NRK Cells Transformed by Temperature-sensitive Rous Sarcoma Virus
- Isoxazole-4-carboxylic Acid as a Metabolite of Streptomyces sp. and Its Herbicidal Activity(Biological Chemistry)
- New Pyrrolobenzodiazepine Antibiotics, RK-1441A and B : II. Isolation and Structure(Organic Chemistry)
- New Pyrrolobenzodiazepine Antibiotics, RK-1441A and B : I. Biological Properties(Organic Chemistry)
- Epiderstatin and Its Related Glutarimide Antibiotics Inhibit the Cell Growth Induced by Mitogen Stimulation(Biological Chemistry)
- Synthesis and Biological Activity of Aminoacyl Analogs of Ascamycin(Organic Chemistry)
- Xanthostatin, a New Antibiotic(Biological Chemistry)
- New Antibiotics, Albopeptins A and B
- Studies on the Mode of Action of Antlermicin A on Bacillus subtHis
- Fatty Acids as Inhibitors of Microbial Cell Wall Synthesis
- Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation
- CRM646-A and -B, Novel Fungal Metabolites that Inhibit Heparinase
- A New Trichostatin Derivative, Trichostatin RK, from Streptomyces sp. RK98-A74
- A Facile and Effective Screening Method p21^ Promoter Activators from Microbial Metabolites
- Morphology Reversion Activity of Phosmidosine and Phosmidosine B, a Newly Isolated Derivative, on src Transformed NRK Cells
- A New Cyclic Lipopeptide Antibiotic, Enamidonin
- Thiazoline Analogues of Epiderstatin, New Inhibitors of Cell Cycle of tsFT-210 Cells
- Preparation of Optically Active Epiderstatin and Its Stereoisomers-Epiderstatin is Not a Real Inhibitor of the Mitogenic Activity Induced by Epidermal Growth Factor-
- Biotransformation of the Mycotoxin, Zearalenone, to a Non-estrogenic Compound by a Fungal Strain of Clonostachys sp.(Organic Chemistry)
- Synthesis of Glycosyl-trehaloses by Cyclomaltodextrin Glucanotransferase through the Transglycosylation Reaction
- Liposidolide A, a New Antifungal Macrolide Antibiotic
- Liposidomycin C Inhibits Phospho-N-acetylmuramyl-pentapeptide Transferase in Peptidoglycan Synthesis of Escherichia coli Y-10(Biological Chemistry)
- Confirmation of the Relative Stereochemistry at C-23 and C-24 of Tautomycin
- Sparoxomycins A1 and A2, New Inducers of the flat Reversion of NRK Cells Transformed by Temperature Sensitive Rous Sarcoma Virus II. Isolation, Physico-chemical Properties and Structure Elucidation
- Polyoxin N, a New Member of the Polyoxin Family
- RK-95113, a New Angiogenesis Inhibitor Produced by Aspergillus fumigatus
- Isolation, and Biological Properties of a New Cell Cycle Inhibitor, Curvularol, Isolated from Curvularia sp. RK97-F166
- Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone
- Factumycin and Its New Derivative RK-1009 Enhance Threonine-phosphorylation of a 60-kDa Protein in Streptomyces griseus
- Cytotrienin A, a Novel Apoptosis Inducer in Human Leukemia HL-60 Cells
- Sparoxomycins A1 and A2, New Inducers of the Flat Reversion of NRK Cells Transformed by Temperature Sensitive Rous Sarcoma Virus I. Taxonomy of the Producing Organism, Fermentation and Biological Activity
- Spirotryprostatin B, a Novel mammalian Cell Cycle Inhibitor Produced by Aspergillus funigatus
- Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B and Other Diketopiperazines Produced by Aspergillus fumigatus II. Physico-chemical Properties and Structures
- Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B and Other Diketopiperazines Produced by Aspergillus fumigatus I. Taxonomy, Fermentation, Isolation and Biological Properties
- Action of a Thermostable Trehalose Synthase from Thermus aquaticus on Sucrose
- Purification and Characterization of a Thermostable Trehalose Synthase from Thermus aquaticus
- Cloning and Sequencing of Trehalose Biosynthesis Genes from Rhizobium sp. M-11
- Enzymatic Synthesis of Glycosyl Cyclic Tetrasaccharide with 6-α-Glucosyltransferase and 3-α-Isomaltosyltransferase(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Synthesis of 3-O-β-N-Acetylglucosaminyl Cyclic Tetrasaccharide through a Lysozyme-catalyzed Transfer Reaction(Biochemistry & Molecular Biology)
- Transglycosylation of Glycosyl Residues to Cyclic Tetrasaccharide by Bacillus stearothermophilus Cyclomaltodextrin Glucanotransferase Using Cyclomaltodextrin as the Glycosyl Donor(Biochemistry & Molecular Biology)
- Production of Cyclic Tetrasaccharide from Starch Using a Novel Enzyme System from Bacillus glob isporus C11
- RS-22A, B and C:New Macrolide Antibiotics from Streptomyces violaceusniger II.Physico-chemical Properties and Structure Elucidation
- Phosphatoquinones A and B, Novel Tyrosine Phosphatase Inhibitors Produced by Streptomyces sp.
- Reduction of Arylcarbonyl Using Zinc Dust in Acetic Acid
- Bioprobes for Investigating Mammalian Cell Cycle Control
- Neopeptins A and B, New Antifungal Antibiotics
- Inhibition of Microbial Cell Wall Synthesis by Lipopeptin A