Actin- and Microtubule-Targeting Bioprobes: Their Binding Sites and Inhibitory Mechanisms

スポンサーリンク

概要

• 論文の詳細を見る

• Actin filaments and microtubules play important biological functions in mammalian cells, such as mitosis, cytokinesis, cell signaling, intracellular transport, and cell motility. Therefore, small molecules that interact with these cytoskeletons are expected to be useful not only as antitumor agents, but also as tools for understanding a wide variety of the cellular functions of cytoskeletons. A large number of compounds have been reported as anti-microtubule or anti-actin agents, but only a few compounds have been clarified as to their binding sites on target molecules and their inhibition mechanisms. Here, I describe our recent research into anti-actin and anti-microtubule natural products. Some inhibitors contain active moieties, such as α,β-unsaturated δ-lactone or allely epoxide, in their structure, and covalently bind to their target molecules. Furthermore, some compounds show new inhibition mechanisms by binding on novel sites in target molecules.

• 社団法人 日本農芸化学会の論文

著者

• Usui Takeo

  Graduate School of Life and Environmental Sciences, University of Tsukuba

関連論文

• Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-κB Signaling by Crosslinking TAK1
• Actin- and Microtubule-Targeting Bioprobes: Their Binding Sites and Inhibitory Mechanisms
• Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-κB Signaling by Crosslinking TAK1
• Actin- and Microtubule-Targeting Bioprobes : Their Binding Sites and Inhibitory Mechanisms
• The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells

スポンサーリンク