Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation(Pharmacognosy)

スポンサーリンク

概要

• 論文の詳細を見る

• Phytoestrogens are naturally occurring compounds exerting estrogenic activity, and include isoflavonoids, flavonoids and lignans. In the present study, we evaluated the stimulating activity of six lignans, meso-dihydroguaiaretic acid, nordihydroguaiaretic acid, machilin A, guaiacin, isoguaiacin and isoguaiacin dimethylether, from Machilus thunbergii, on osteoblast differentiation employing primary cultures of mouse osteoblast as an in vitro assay system. Among the six lignans tested, arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increased alkaline phosphatase activity, whereas bibenzylbutane type lignans such as meso-dihydroguaiaretic acid, nordihydroguaiaretic acid and machilin A showed little effects. Isoguaiacin and isoguaiacin dimethylether also increased collagen synthesis as well as calcium deposition. In addition, treatment of the mouse osteoblasts with tamoxifen markedly reduced ALP activity increased by isoguaiacin or isoguaiacin dimethylether, suggesting the involvement of estrogen receptor in the action of these lignans on osteoblast differentiation. Taken together, these results suggest that arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increase osteoblast differentiation.

• 公益社団法人日本薬学会の論文
• 2007-04-01

著者

• Kim Young

  College of Pharmacy, Chungnam National University

• Lee Mi

  College Of Veterinary Medicine Chonbuk National University

• Kim Young

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Lee Mi

  Coll. Of Pharmacy Chungbuk National Univ.

• YANG Hyekyung

  College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University

• MA Choong

  College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University

• Ma Choong

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Yang Hyekyung

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Lee Mi

  College Of Pharmacy Chungbuk National University

• Lee Mi

  College of Pharmacy and Medical Research Center, Chungbuk National University

• Kim Young

  Colledge of Pharmacy, Wonkwang University

関連論文

• Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
• Phenolic Compounds from Artemisia iwayomogi and Their Effects on Osteoblastic MC3T3-E1 Cells
• Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis : Inhibition of the PKCδ/JNK/c-Jun Pathway
• Lipid production in Porphyridium cruentum grown under different culture conditions(BIOCHEMICAL ENGINEERING)
• Enhanced Solubility and Bioavailability of Sibutramine Base by Solid Dispersion System with Aqueous Medium
• Inhibitory Effects of Coumarins from the Stem Barks of Fraxinus rhynchophylla on Adipocyte Differentiation in 3T3-L1 Cells
• New Neolignan Component from Camellia amplexicaulis and Effects on Osteoblast Differentiation
• Defects study of retrograde twin well CMOS that has MeV ion implanted buried layer
• Defects study of retrograde twin well CMOS that has MeV ion implanted buried layer
• New Triterpenoid Saponins from Glochidion eriocarpum and Their Cytotoxic Activity
• Chemical Constituents from the Leaves of Manglietia phuthoensis and Their Effects on Osteoblastic MC3T3-E1 Cells
• New Cembranoid Diterpenes from the Vietnamese Soft Coral Sarcophyton mililatensis Stimulate Osteoblastic Differentiation in MC3T3-E1 Cells
• Caesaldecan, a Cassane Diterpenoid from the Leaves of Caesalpinia decapetala
• Lupane-triterpene Carboxylic Acids from the Leaves of Acanthopanax trifoliatus
• Quinolone Alkaloids with Inhibitory Activity against Nuclear Factor of Activated T Cells from the Fruits of Evodia rutaecarpa(Pharmacognosy)
• Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats
• A Novel Cerebroside from Lycii Fructus Preserves the Hepatic Glutathione Redox System in Primary Cultures of Rat Hepatocytes
• A New Monoterpenoid Glycoside from Myrica esculenta and the Inhibition of Angiotensin I-Converting Enzyme
• α-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of Momordica charantia
• Lupane Triterpene Glycosides from Leave of Acanthopanax koreanum and Their Cytotoxic Activity
• Phenylplropene A and B, New Inhibitors of Acyl-CoA : Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959
• Effects of Dimethylsulfoxide on Metabolism and Toxicity of Acetaminophen in Mice(Pharmacology)
• Sauchinone, a Lignan from Saururus chinensis, Attenuates CCl_4-Induced Toxicity in Primary Cultures of Rat Hepatocytes
• Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain
• (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
• Two New Dammarane-Type Saponins from the Leaves of Panax ginseng
• Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
• Two New Neolignans from the Aerial Parts of Rodgersia podophylla
• Two New Acylated Iridoid Glucosides from the Aerial Parts of Paederia scandens
• Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum
• Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats
• Hepatoprotective Dibenzylbutyrolactone Lignans of Torreya nucifera against CCl_4-Induced Toxicity in Primary Cultured Rat Hepatocytes(Pharmacognosy)
• Sauchinone, a Lignan from Saururus chinensis, Inhibits Staurosporine-Induced Apoptosis in C6 Rat Glioma Cells(Pharmacognosy)
• Gymnasterkoreayne G, a New Inhibitory Polyacetylene against NFAT Transcription Factor from Gymnaster koraiensis
• New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense
• Oleanane Triterpenoids with Inhibitory Activity against NFAT Transcription Factor from Liquidambar formosana (Pharmacognosy)
• 44-Homooligomycilm E, a New Cytotoxic Macrolide Antibiotic from Streptomyces ostreogriseus
• 41-Demethylhomooligomycin B, a New Immunosuppresant Antibiotic from Streptomyces ostreogriseus
• Aclacinomycin X, a Novel Anthracycline Antibiotic Produced by Streptomyces galilaeus ATCC 31133
• Anti-inflammatory Activity of the Synthetic Chalcone Derivatives : Inhibition of Inducible Nitric Oxide Synthase-Catalyzed Nitric Oxide Production from Lipopolysaccharide-Treated RAW 264.7 Cells(Pharmacology)
• Crinamine from Crinum asiaticum var. japonicum Inhibits Hypoxia Inducible Factor-1 Activity But Not Activity of Hypoxia Inducible Factor-2(Pharmacognosy)
• New Pyrano-Pyrone from Goniothalamus tamirensis Enhances the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
• A New Neuroprotective Pinusolide Derivative from the Leaves of Biota orientalis
• New Tetrahydrofuran-Type Sesquilignans of Saurus chinensis Root
• Effect of Dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
• Inverse Relationship between Adipocyte Differentiation and Ceramide Level in 3T3-L1 Cells
• Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells
• Effect of Taurine on Biliary Excretion and Metabolism of Acetaminophen in Male Hamsters(Toxicology)
• Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation(Pharmacognosy)
• Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells
• Acteoside of Callicarpa dichotoma Attenuates Scopolamine-Induced Memory Impairments(Pharmacology)
• Effects of Carbon Tetrachloride Pretreat-ment on Hepato- and Nephrotoxicity of Halogenated Hydrocarbons in Mice
• Total Peroxynitrite Scavenging Capacity of Phenylethanoid and Flavonoid Glycosides from the Flowers of Buddleja officinalis
• Prodomain Processing of Recombinant Plasmepsin II and IV, the Aspartic Proteases of Plasmodium falciparum, Is Auto- and Trans-Catalytic
• Oleanolic Triterpene Saponins from the Roots of Panax bipinnatifidus
• The antioxidant effects of Joongpoongtang 05 on brain injury after transient focal cerebral ischemia in rats
• Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells
• Triterpenoids from Camellia japonica and Their Cytotoxic Activity
• New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus
• Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
• (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a Cembrenolide Diterpene from Soft Coral Lobophytum sp., Inhibits Growth and Induces Apoptosis in Human Colon Cancer Cells through Reactive Oxygen Species Generation
• Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities
• Diterpenoids from the Soft Coral Sinularia maxima and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
• Antifibrotic Activity of Diarylheptanoids from Betula platyphylla toward HSC-T6 Cells
• Triterpenoid Saponins of Pulsatilla koreana Root Have Inhibition Effects of Tumor Necrosis Factor-α Secretion in Lipopolysaccharide-Induced RAW264.7 Cells

もっと見る 閉じる

スポンサーリンク