(1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a Cembrenolide Diterpene from Soft Coral Lobophytum sp., Inhibits Growth and Induces Apoptosis in Human Colon Cancer Cells through Reactive Oxygen Species Generation
スポンサーリンク
概要
- 論文の詳細を見る
We observed that (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide (LS-1), marine cembrenolide diterpene, inhibited growth and induced apoptosis in colon cancer cells via a reactive oxygen species (ROS) dependent mechanism. Treatment of HT-29 cells with LS-1 resulted in ROS generation, which was accompanied by disruption of mitochondrial membrane potential, cytosolic release of cytochrome c, sub-G1 peak accumulation, activation of Bid, caspase-3, -8, and -9, and cleavage of poly(ADP-ribose) polymerase (PARP) along with the suppressive expression of B cell lymphoma-2 (Bcl-2). All these effects were significantly blocked on pretreatment with the ROS inhibitor N-acetylcysteine (NAC), indicating the involvement of increased ROS in the proapoptotic activity of LS-1. Moreover, we showed that LS-1 induced the phosphorylation of c-Jun N-terminal kinase (JNK) and dephosphorylation of p38, extracellular signal-regulated kinase (ERK), Akt, Src and signal transducer and activator of transcription (STAT)3, which were effectively attenuated by NAC. In addition, the expressions of antioxidant catalase and glutathione peroxidase were abrogated by treatment using LS-1 with or without NAC. These findings reveal the novel anticancer efficacy of LS-1 mediated by the induction of apoptosis via ROS generation in human colon cancer cells.
著者
-
Kim Gi
Department Of Electrical Engineering Faculty Of Engineering Osaka University
-
Kim Young
Institute Of Natural Medicine University Of Toyama
-
Hyun Chang
Institute Of Basic Science Sungkyunkwan University:department Of Physics Seoul National University
-
Chang Weon
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Kim Young
Colledge of Pharmacy, Wonkwang University
-
Hong Ji-Young
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Boo Hye-Jin
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Kang Jung-Il
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Kim Min-Kyoung
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Yoo Eun-Sook
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Hyun Jin-Won
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Koh Young-Sang
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Maeng Young
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Kang Hee-Kyoung
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Hyun Chang
Institute of Medical Sciences, School of Medicine, Jeju National University
-
Kim Gi
Department of Marine Life Sciences, Jeju National University
-
Kim Young
Institute of Medical Sciences, School of Medicine, Jeju National University
-
KIM Young
Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University
-
KIM Young
Institute for Livestock Promotion, Jeju Special Self-Governing Province, Jeju 690-180, Korea
関連論文
- Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
- Phenolic Compounds from Artemisia iwayomogi and Their Effects on Osteoblastic MC3T3-E1 Cells
- Understanding the accumulation features of POPs in squid from the offshore waters of southeast Korea
- Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis : Inhibition of the PKCδ/JNK/c-Jun Pathway
- Lipid production in Porphyridium cruentum grown under different culture conditions(BIOCHEMICAL ENGINEERING)
- Enhanced Solubility and Bioavailability of Sibutramine Base by Solid Dispersion System with Aqueous Medium
- Behavioral Reactivity of Jindo Dogs Socialized at an Early Age Compared with Non-Socialized Dogs
- New Neolignan Component from Camellia amplexicaulis and Effects on Osteoblast Differentiation
- New Triterpenoid Saponins from Glochidion eriocarpum and Their Cytotoxic Activity
- Chemical Constituents from the Leaves of Manglietia phuthoensis and Their Effects on Osteoblastic MC3T3-E1 Cells
- New Cembranoid Diterpenes from the Vietnamese Soft Coral Sarcophyton mililatensis Stimulate Osteoblastic Differentiation in MC3T3-E1 Cells
- Caesaldecan, a Cassane Diterpenoid from the Leaves of Caesalpinia decapetala
- Lupane-triterpene Carboxylic Acids from the Leaves of Acanthopanax trifoliatus
- Quinolone Alkaloids with Inhibitory Activity against Nuclear Factor of Activated T Cells from the Fruits of Evodia rutaecarpa(Pharmacognosy)
- Protective Effect of Grape Seed Polyphenols against High Glucose-Induced Oxidative Stress
- Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats
- A Novel Cerebroside from Lycii Fructus Preserves the Hepatic Glutathione Redox System in Primary Cultures of Rat Hepatocytes
- A New Monoterpenoid Glycoside from Myrica esculenta and the Inhibition of Angiotensin I-Converting Enzyme
- α-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of Momordica charantia
- Lupane Triterpene Glycosides from Leave of Acanthopanax koreanum and Their Cytotoxic Activity
- Phenylplropene A and B, New Inhibitors of Acyl-CoA : Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959
- Comparative Analysis of Vocalizations of Thoroughbred Mares (Equus caballus) between Estrus and Diestrus
- Effects of Dimethylsulfoxide on Metabolism and Toxicity of Acetaminophen in Mice(Pharmacology)
- Sauchinone, a Lignan from Saururus chinensis, Attenuates CCl_4-Induced Toxicity in Primary Cultures of Rat Hepatocytes
- Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain
- (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
- Two New Dammarane-Type Saponins from the Leaves of Panax ginseng
- Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
- Two New Neolignans from the Aerial Parts of Rodgersia podophylla
- Two New Acylated Iridoid Glucosides from the Aerial Parts of Paederia scandens
- Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum
- Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats
- Hepatoprotective Dibenzylbutyrolactone Lignans of Torreya nucifera against CCl_4-Induced Toxicity in Primary Cultured Rat Hepatocytes(Pharmacognosy)
- Sauchinone, a Lignan from Saururus chinensis, Inhibits Staurosporine-Induced Apoptosis in C6 Rat Glioma Cells(Pharmacognosy)
- Electron Transport in Hydrogenated Amorphous Silicon Prepared by rf Sputtering : II-1: AMORPHOUS FILM PREPARATION AND CHARACTERIZATION (I)
- Photoluminescence and Optical Properties of Ge_Se_x Glasses
- Transport of Photoexcited Carriers in Evaporated Ge_xSe_ Glass Films
- Dispersive Transport in Hydrogenated a-Si Prepared by rf Sputtering : III-2: AMORPHOUS SOLAR CELLS : Characterization
- Gymnasterkoreayne G, a New Inhibitory Polyacetylene against NFAT Transcription Factor from Gymnaster koraiensis
- New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense
- Oleanane Triterpenoids with Inhibitory Activity against NFAT Transcription Factor from Liquidambar formosana (Pharmacognosy)
- Anti-inflammatory Activity of the Synthetic Chalcone Derivatives : Inhibition of Inducible Nitric Oxide Synthase-Catalyzed Nitric Oxide Production from Lipopolysaccharide-Treated RAW 264.7 Cells(Pharmacology)
- Crinamine from Crinum asiaticum var. japonicum Inhibits Hypoxia Inducible Factor-1 Activity But Not Activity of Hypoxia Inducible Factor-2(Pharmacognosy)
- New Pyrano-Pyrone from Goniothalamus tamirensis Enhances the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
- A New Neuroprotective Pinusolide Derivative from the Leaves of Biota orientalis
- New Tetrahydrofuran-Type Sesquilignans of Saurus chinensis Root
- Effect of Dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
- Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells
- Effect of Taurine on Biliary Excretion and Metabolism of Acetaminophen in Male Hamsters(Toxicology)
- Specific accumulation of heavy metals in squid collected from offshore Korean waters : preliminary results for offshore biomonitoring and food safety assessment
- Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation(Pharmacognosy)
- C303 ENCLOSED CONVECTION WITH INTERNAL HEAT GENERATION UNDER OSCILLATING BOUNDARY WALL(Mixed convection)
- Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells
- Acteoside of Callicarpa dichotoma Attenuates Scopolamine-Induced Memory Impairments(Pharmacology)
- Effects of Carbon Tetrachloride Pretreat-ment on Hepato- and Nephrotoxicity of Halogenated Hydrocarbons in Mice
- Total Peroxynitrite Scavenging Capacity of Phenylethanoid and Flavonoid Glycosides from the Flowers of Buddleja officinalis
- Time of Flight Measurement of Carrier Mobility in Ge_xSe_ Glasses
- Oleanolic Triterpene Saponins from the Roots of Panax bipinnatifidus
- The antioxidant effects of Joongpoongtang 05 on brain injury after transient focal cerebral ischemia in rats
- Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells
- Compatibility of Exotic States with Neutron Star Observation(Hadronic matter and equation of state, Chiral dynamics in nuclear medium, New Frontiers in QCD-Exotic Hadrons and Hadronic Matter-)
- New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus
- Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
- Influence of Li_2O on the Viscous Behavior of CaO-Al_2O_3-12 mass% Na_2O-12 mass% CaF_2 Based Slags
- (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a Cembrenolide Diterpene from Soft Coral Lobophytum sp., Inhibits Growth and Induces Apoptosis in Human Colon Cancer Cells through Reactive Oxygen Species Generation
- Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities
- Diterpenoids from the Soft Coral Sinularia maxima and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
- Antifibrotic Activity of Diarylheptanoids from Betula platyphylla toward HSC-T6 Cells
- Post-death Cloning of Endangered Jeju Black Cattle (Korean Native Cattle): Fertility and Serum Chemistry in a Cloned Bull and Cow and Their Offspring
- Triterpenoid Saponins of Pulsatilla koreana Root Have Inhibition Effects of Tumor Necrosis Factor-α Secretion in Lipopolysaccharide-Induced RAW264.7 Cells
- ISO-4-4 Learning curve analysis and training of robot-assisted laparoscopy for cervical cancer : initial experience at a single institution(Group 4 Oncology 2,IS Award Candidate,International Session)
- ISP-18-6 The role of gastro-intestinal endoscopy as an adjunct preoperative workup in Ovarian Cancer Patients(Group 18 Oncology 9,IS Poster,International Session)
- ISP-19-5 Laparoscopy for the management of early-stage ovarian cancer : A meta-analysis of single-arm studies(Group 19 Oncology 10,IS Poster,International Session)
- Microbial inactivation and pesticide removal by remote exposure of atmospheric air plasma in confined environments(BIOCHEMICAL ENGINEERING)