Protective Effect of Grape Seed Polyphenols against High Glucose-Induced Oxidative Stress
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概要
- 論文の詳細を見る
We aimed to clarify whether grape seed polyphenols (GSPs) are candidates therapeutic agents against diabetes mellitus, and to determine what degree of GSP oligomerization has the most potent efficacy. We studied the protective effects of various molecular weight GSPs (monomer, oligomer, polymer, and oligonol) on high glucose-induced cytotoxicity. In the present study, a high concentration of glucose (30 mM) induced cytotoxicity and oxidative stress (reactive oxygen species and nitric oxide) in cultured LLC-PK1 cells, but treatment with GSPs, especially oligomer GSPs, had potent protective effects against high glucose-induced oxidative stress. In addition, high glucose induced nuclear translocation of nuclear factor-kappa B, and increased expression of cyclooxygenase-2, inducible nitric oxide synthase, and bax, but GSP treatment inhibited them. These results indicate that GSPs have protective effects against high glucose-induced cytotoxicity, and among them, oligomer GSPs have more potent effects than other GSPs (monomer, polymer, and oligonol) on high glucose-induced renal cell damage.
- 社団法人 日本農芸化学会の論文
- 2007-09-23
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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YOSHIDA Munehiro
Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials and Bioengineering, Kan
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NISHIYAMA Toshimasa
Department of Public Health, Kansai Medical University
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FUKUNAGA Kenji
Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials and Bioengineering, Kan
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Nonaka G
Faculty Of Pharmaceutical Sciences Kyushu University
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NONAKA Gen-ichiro
Usaien Pharm. Co., Ltd.
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Fujii Hajime
Institute Of Natural Medicine University Of Toyama
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Yokozawa Takako
富山大学和漢医薬学総合研究所
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KIM Young
Institute of Natural Medicine, University of Toyama
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TOHDA Chihiro
Institute of Natural Medicine, University of Toyama
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Yoshida Munehiro
Laboratory Of Food And Nutritional Science Department Of Biotechnology Faculty Of Engineering Kansai
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Nishiyama Toshimasa
Department Of Parasitology Nara Medical University
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Yokozawa T
Institute Of Natural Medicine University Of Toyama
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Kim Young
Institute Of Natural Medicine University Of Toyama
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Fujii H
Institute Of Genetic Resources Faculty Of Agriculture Kyushu University
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OKADA Toshihide
Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Ka
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NAMIKAWA Yuichi
Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Ka
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MATSUZAKI Yoshimi
Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Ka
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Okada Toshihide
Laboratory Of Food And Nutritional Sciences Department Of Biotechnology Faculty Of Engineering Kansa
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Fukunaga Kenji
Laboratory Of Food And Nutritional Sciences Department Of Biotechnology Faculty Of Engineering Kansa
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Matsuzaki Yoshimi
Laboratory Of Food And Nutritional Sciences Department Of Biotechnology Faculty Of Engineering Kansa
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Kim Young
Laboratory Of Molecular Plant Pathology College Of Life And Environmental Scinces Korea University
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Yoshida Munehiro
Laboratory Of Food And Nutritional Sciences Department Of Biotechnology Faculty Of Engineering Kansa
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Namikawa Yuichi
Laboratory Of Food And Nutritional Sciences Department Of Biotechnology Faculty Of Engineering Kansa
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Fujii Hajime
Laboratory of Insect Genetic Resources, Faculty of Agriculture, Kyushu University
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Yokozawa Takako
Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University
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